Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 15/20 | 0.43 |
| ▸ | LCK | P06239 | 14/20 | 0.43 |
| ▸ | BTK | Q06187 | 4/20 | 0.43 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 7/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30160648 | 0.89 | JAK3 (0.42) | JAK3LCKBTKGPBAR1EGFR | |
| SCHEMBL24833599 | 0.89 | JAK3 (0.42) | JAK3LCKBTKGPBAR1EGFR | |
| SCHEMBL24834042 | 0.77 | KDM4E (0.39) | JAK3LCKBTKEGFR | |
| SCHEMBL31097402 | 0.76 | JAK3 (0.37) | JAK3LCKBTKEGFR | |
| SCHEMBL30356545 | 0.76 | JAK3 (0.48) | JAK3LCKBTKEGFR | |
| SCHEMBL31591131 | 0.74 | JAK3 (0.42) | JAK3LCKBTKEGFR | |
| SCHEMBL16764192 | 0.74 | JAK3 (0.53) | JAK3LCKBTKEGFR | |
| SCHEMBL29871862 | 0.74 | JAK3 (0.53) | JAK3LCKBTKEGFR | |
| SCHEMBL16764194 | 0.74 | JAK3 (0.53) | JAK3LCKBTKEGFR | |
| SCHEMBL30165821 | 0.74 | JAK3 (0.54) | JAK3LCKBTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023274390-A1 | BRUTON'S TYROSINE KINASE AND MUTANT DEGRADER, COMPOSITION AND APPLICATION THEREOF | 杭州和正医药有限公司 | 2023-01-05 | — | — | WO | disclosed |