Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 5/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31325032 | 0.86 | TSHR (0.41) | NLRP3TSHRSMN1; SMN2HTTP2RX3 | |
| SCHEMBL24834534 | 0.83 | NLRP3 (0.51) | NLRP3TSHRSMN1; SMN2HTTP2RX3 | |
| SCHEMBL24077191 | 0.83 | NLRP3 (0.48) | NLRP3TSHRSMN1; SMN2HTTNPSR1 | |
| SCHEMBL31325030 | 0.82 | NLRP3 (0.49) | NLRP3TSHRSMN1; SMN2HTTP2RX3 | |
| SCHEMBL24834533 | 0.81 | ALOX15 (0.54) | TSHRALOX15AKR1B1 | |
| SCHEMBL24076969 | 0.78 | ALOX15 (0.60) | NLRP3TSHRSMN1; SMN2HTTNPSR1 | |
| SCHEMBL24834532 | 0.77 | NLRP3 (0.45) | NLRP3NPSR1TP53ALOX15KMT2A | |
| SCHEMBL24076253 | 0.77 | NLRP3 (0.52) | NLRP3TSHRSMN1; SMN2HTTNPSR1 | |
| SCHEMBL24077164 | 0.77 | NLRP3 (0.52) | NLRP3TSHRSMN1; SMN2HTTNPSR1 | |
| SCHEMBL24834482 | 0.77 | CYP2C19 (0.49) | TSHRSMN1; SMN2HTTKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023275230-A1 | 5-OXO-PYRIDO[2,3-D]PYRIDAZIN-6(5H)-YL ACETAMIDES | JANSSEN PHARMACEUTICA NV (BE) | 2023-01-05 | — | — | WO | disclosed |