SCHEMBL24834841

SCHEMBL24834841

Cc1nccnc1-c1nn2c(=O)cc(-c3ccc(C4CCC(F)(F)CC4)cc3)[nH]c2c1C(=O)N1CC(CF)C1

nearest known ligand 0.35

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PLAT P00750 12/20 0.35
S1PR4 O95977 1/20 0.32
S1PR1 P21453 1/20 0.32
S1PR3 Q99500 1/20 0.32
S1PR5 Q9H228 1/20 0.32
CCR5 P51681 1/20 0.31
TLR9 Q9NR96 1/20 0.30
TLR8 Q9NR97 1/20 0.30
TLR7 Q9NYK1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24834786 0.93 PLAT (0.37) PLAT
SCHEMBL24834880 0.92 PLAT (0.36) PLAT
SCHEMBL29785416 0.92 PLAT (0.36) PLAT
SCHEMBL23415597 0.86 ALDH1A1 (0.33) PLAT
SCHEMBL23415398 0.86 PLAT (0.35) PLAT
SCHEMBL24834789 0.86 PLAT (0.33) PLAT
SCHEMBL24834801 0.84 PLAT (0.32) PLAT
SCHEMBL24834859 0.83 PLAT (0.36) PLAT
SCHEMBL24834809 0.83 PLAT (0.34) PLAT
SCHEMBL29785492 0.83 PLAT (0.36) PLAT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114786778-A Therapeutic compounds 基因泰克公司 2022-07-22 CN claimed
US-20230002396-A1 THERAPEUTIC COMPOUNDS GENENTECH, INC. (US) 2023-01-05 US disclosed
US-20230002396-A1 THERAPEUTIC COMPOUNDS GENENTECH, INC. (US) 2023-01-05 US disclosed
CN-114786778-A Therapeutic compounds 基因泰克公司 2022-07-22 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230002396-A1 THERAPEUTIC COMPOUNDS YAP1, YES1, TEAD2 PLAT 3745/4885S1PR4 4612/4885S1PR1 4283/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.