Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.38 |
| ▸ | SLC6A9 | P48067 | 5/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1742169 | 0.91 | ALDH1A1 (0.49) | ALDH1A1HPGDKDM4EMAPTSLC6A4 | |
| SCHEMBL1743546 | 0.83 | SLC6A4 (0.46) | ALDH1A1HPGDKDM4EMAPTSLC6A4 | |
| SCHEMBL9323438 | 0.77 | HSD17B10 (0.48) | ALDH1A1HPGDKDM4EMAPTL3MBTL1 | |
| SCHEMBL18123682 | 0.76 | KDM4E (0.54) | ALDH1A1HPGDKDM4EMAPTTDP1 | |
| SCHEMBL10597129 | 0.75 | ALDH1A1 (0.47) | ALDH1A1KDM4EMAPTTDP1L3MBTL1 | |
| SCHEMBL9323068 | 0.75 | ABL1 (0.53) | ALDH1A1HPGDKDM4EMAPTSLC6A4 | |
| SCHEMBL8113878 | 0.74 | CFTR (0.56) | ALDH1A1HPGDKDM4EMAPTSLC6A4 | |
| SCHEMBL18641503 | 0.74 | MAPT (0.46) | ALDH1A1HPGDKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL5887723 | 0.74 | SIRT1 (0.61) | ALDH1A1KDM4EMAPTSLC6A3TDP1 | |
| SCHEMBL28189180 | 0.72 | SIRT1 (0.54) | ALDH1A1KDM4EMAPTSLC6A3TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376480-A2 | SULFONAMIDE DERIVATIVES AS BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES | Abbott Laboratories (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010065865-A2 | BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2010-06-10 | — | — | WO | disclosed |