SCHEMBL5887723

SCHEMBL5887723

COC(=O)c1ccccc1Sc1ccccc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIRT1 Q96EB6 1/20 0.61
HSD17B10 Q99714 2/20 0.57
POLB P06746 2/20 0.57
MAPT P10636 4/20 0.56
PKLR P30613 1/20 0.54
TSHR P16473 3/20 0.52
LMNA P02545 1/20 0.52
L3MBTL1 Q9Y468 3/20 0.51
ALDH1A1 P00352 1/20 0.50
CFTR P13569 1/20 0.50
TDP1 Q9NUW8 2/20 0.49
ALOX15 P16050 1/20 0.49
KDM4E B2RXH2 1/20 0.49
ATM Q13315 1/20 0.49
HTT P42858 1/20 0.48
KMT2A Q03164 2/20 0.48
SLC6A3 Q01959 1/20 0.47
PABPC1 P11940 1/20 0.47
EIF4H Q15056 1/20 0.47
MEN1 O00255 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28189180 0.94 SIRT1 (0.54) SIRT1HSD17B10POLBMAPTPKLR
SCHEMBL4440485 0.89 HSD17B10 (0.64) HSD17B10POLBMAPTPKLRTSHR
SCHEMBL6934406 0.88 HSD17B10 (0.53) SIRT1HSD17B10POLBMAPTPKLR
SCHEMBL14176672 0.88 MAPT (0.56) SIRT1HSD17B10POLBMAPTPKLR
SCHEMBL6934243 0.84 SMN1; SMN2 (0.50) SIRT1HSD17B10POLBMAPTPKLR
SCHEMBL19599641 0.84 SLC6A9 (0.49) SIRT1HSD17B10POLBMAPTPKLR
SCHEMBL12772114 0.84 ALDH1A1 (0.51) SIRT1HSD17B10POLBMAPTPKLR
SCHEMBL9323438 0.83 HSD17B10 (0.48) SIRT1HSD17B10POLBMAPTTSHR
SCHEMBL4802025 0.83 MAPT (0.55) SIRT1HSD17B10POLBMAPTPKLR
SCHEMBL11665329 0.82 ALDH1A1 (0.55) SIRT1HSD17B10MAPTPKLRTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10416558-B2 Positive resist composition, resist pattern forming process, and photomask blank SHIN-ETSU CHEMICAL CO., LTD. (JP) 2019-09-17 US disclosed
US-10248022-B2 Sulfonium compound, making method, resist composition, and pattern forming process SHIN-ETSU CHEMICAL CO., LTD. (JP) 2019-04-02 US disclosed
EP-3279734-B1 POSITIVE RESIST COMPOSITION, RESIST PATTERN FORMING PROCESS, AND PHOTOMASK BLANK SHINETSU CHEMICAL CO (JP) 2018-07-25 EP disclosed
US-20180039175-A1 NEGATIVE RESIST COMPOSITION AND RESIST PATTERN FORMING PROCESS SHIN-ETSU CHEMICAL CO., LTD. (JP) 2018-02-08 US disclosed
US-20180039175-A1 NEGATIVE RESIST COMPOSITION AND RESIST PATTERN FORMING PROCESS SHIN-ETSU CHEMICAL CO., LTD. (JP) 2018-02-08 US disclosed
US-20180039177-A1 POSITIVE RESIST COMPOSITION, RESIST PATTERN FORMING PROCESS, AND PHOTOMASK BLANK SHIN-ETSU CHEMICAL CO., LTD. (JP) 2018-02-08 US disclosed
US-20180039177-A1 POSITIVE RESIST COMPOSITION, RESIST PATTERN FORMING PROCESS, AND PHOTOMASK BLANK SHIN-ETSU CHEMICAL CO., LTD. (JP) 2018-02-08 US disclosed
EP-3279729-A1 NEGATIVE RESIST COMPOSITION AND RESIST PATTERN FORMING PROCESS Shin-Etsu Chemical Co., Ltd. (JP) 2018-02-07 EP disclosed
EP-3279734-A1 POSITIVE RESIST COMPOSITION, RESIST PATTERN FORMING PROCESS, AND PHOTOMASK BLANK Shin-Etsu Chemical Co., Ltd. (JP) 2018-02-07 EP disclosed
US-20170329227-A1 NOVEL SULFONIUM COMPOUND, MAKING METHOD, RESIST COMPOSITION, AND PATTERN FORMING PROCESS SHIN-ETSU CHEMICAL CO., LTD. (JP) 2017-11-16 US disclosed
US-20170329227-A1 NOVEL SULFONIUM COMPOUND, MAKING METHOD, RESIST COMPOSITION, AND PATTERN FORMING PROCESS SHIN-ETSU CHEMICAL CO., LTD. (JP) 2017-11-16 US disclosed
CN-101687781-B Compound for photoacid generator and use its anti-corrosion agent composition, pattern formation method CENTRAL GLASS CO.,LTD. (JP) 2015-08-12 CN disclosed
EP-2325190-B1 Composition for charge-transporting film and ion compound, charge-transporting film and organic electroluminescent device using same MITSUBISHI CHEM CORP (JP) 2013-05-08 EP disclosed
CN-101687781-A Compound for photoacid generator, resist composition using the same, and pattern-forming method CENTRAL GLASS CO LTD 2010-03-31 CN disclosed
US-20080070963-A1 Compositions and methods for promoting neural regeneration Neuberger, Timothy 2008-03-20 US disclosed
US-7271187-B2 Compositions and methods for promoting tissue regeneration Neuberger, Tim (US) 2007-09-18 US disclosed
US-7112697-B1 Methods for formation of aryl-sulfur and aryl-selenium compounds using copper(I) catalysts UNIVERSITY OF MASSACHUSETTS (US) 2006-09-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080070963-A1 Compositions and methods for promoting neural regeneration GAP43, DCX, BDNF SIRT1 2570/4885HSD17B10 1213/4885POLB 3014/4885
US-10416558-B2 Positive resist composition, resist pattern forming process, and photomask blank LRRC47, SLIRP, COPE SIRT1 4786/4885HSD17B10 3986/4885POLB 204/4885
US-10248022-B2 Sulfonium compound, making method, resist composition, and pattern forming process HNRNPU, C1R, LBR SIRT1 4632/4885HSD17B10 2326/4885POLB 2111/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.