Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 6/20 | 0.59 |
| ▸ | DRD2 | P14416 | 1/20 | 0.59 |
| ▸ | KDM1A | O60341 | 1/20 | 0.55 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PLA2G6 | O60733 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30477104 | 1.00 | SLC6A4 (0.59) | SLC6A4DRD2KDM1AMTNR1ASLC6A2 | |
| SCHEMBL3968194 | 0.91 | SLC6A4 (0.56) | SLC6A4DRD2KDM1AMTNR1ASLC6A2 | |
| SCHEMBL497994 | 0.91 | SLC6A4 (0.56) | SLC6A4DRD2KDM1AMTNR1ASLC6A2 | |
| SCHEMBL7650624 | 0.90 | SLC6A4 (0.55) | SLC6A4DRD2KDM1AMTNR1ASLC6A2 | |
| SCHEMBL28701417 | 0.90 | SLC6A4 (0.51) | SLC6A4DRD2KDM1AMTNR1ASLC6A2 | |
| SCHEMBL24034816 | 0.90 | SLC6A4 (0.51) | SLC6A4DRD2KDM1AMTNR1ASLC6A2 | |
| SCHEMBL4047901 | 0.89 | SLC6A4 (0.54) | SLC6A4DRD2KDM1AMTNR1ASLC6A2 | |
| SCHEMBL30032791 | 0.89 | SLC6A4 (0.54) | SLC6A4DRD2KDM1AMTNR1ASLC6A2 | |
| SCHEMBL168782 | 0.89 | SLC6A4 (0.54) | SLC6A4DRD2KDM1AMTNR1ASLC6A2 | |
| SCHEMBL8747043 | 0.88 | MTNR1A (0.50) | SLC6A4DRD2KDM1AMTNR1AIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 324 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115417825-B | Five-membered or six-membered fused ring pyrimidine cyclopropyl naphthalene derivative and preparation method and application thereof | 山东大学 | 2024-06-28 | — | — | CN | claimed |
| WO-2023143034-A1 | PYRIDOIMIDAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 山东大学 | 2023-08-03 | — | — | WO | claimed |
| CN-114907344-B | Beta-carboline-1-propionic acid and indole derivatives, and preparation method and application thereof | 山东大学 | 2023-06-30 | — | — | CN | claimed |
| EP-4165033-A1 | SHP2 INHIBITORS, COMPOSITIONS AND USES THEREOF | Betta Pharmaceuticals Co., Ltd (CN) | 2023-04-19 | — | — | EP | claimed |
| CN-115417825-A | Five-membered or six-membered fused ring pyrimidine cyclopropyl naphthalene derivative and preparation method and application thereof | 山东大学 | 2022-12-02 | — | — | CN | claimed |
| CN-114907344-A | Beta-carboline-1-propionic acid and indole derivatives, and preparation method and application thereof | 山东大学 | 2022-08-16 | — | — | CN | claimed |
| CN-114874232-A | Preparation method and application of thienopyrimidinone compound containing ethyl naphthalene structure | 山东大学 | 2022-08-09 | — | — | CN | claimed |
| CN-114478522-A | Pyridoimidazole derivative and preparation method and application thereof | 山东大学 | 2022-05-13 | — | — | CN | claimed |
| WO-2021249449-A1 | SHP2 INHIBITORS, COMPOSITIONS AND USES THEREOF | BETTA PHARMACEUTICALS CO., LTD (CN) | 2021-12-16 | — | — | WO | claimed |
| US-11173146-B2 | Selective activators of the intermediate conductance CA2+activated K+ channel KCa3.1 and their methods of use | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-11-16 | — | — | US | claimed |
| CN-105175414-A | Imidazole [4,5-b] pyridine mercaptoacetamide derivative as well as preparation method and application thereof | UNIV SHANDONG | 2015-12-23 | — | — | CN | claimed |
| WO-2015164816-A2 | SELECTIVE ACTIVATORS OF THE INTERMEDIATE CONDUCTANCE CA2+-ACTIVATED K+ CHANNEL KCA3.1 AND THEIR METHODS OF USE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-10-29 | — | — | WO | claimed |
| CN-104788318-A | Method for preparing 4-nitro-cyclopropyl-naphthalene | ASTATECH CHENGDU PHARM CO LTD | 2015-07-22 | — | — | CN | claimed |
| WO-2014198241-A1 | THIO-1,2,4-TRIAZOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2014-12-18 | — | — | WO | claimed |
| CN-104016927-A | Pyrimidine thiol acetamide ramification as well as preparation method and application thereof | UNIV SHANDONG | 2014-09-03 | — | — | CN | claimed |
| CN-101899013-A | 2-(2-substituted aryl-2H-1,2,4-triazole-3-sulfydryl) acetamide derivative and preparation method and application thereof | UNIV SHANDONG | 2010-12-01 | — | — | CN | claimed |
| EP-1654225-A4 | MELANIN CONCENTRATING HORMONE RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2007-11-28 | — | — | EP | claimed |
| EP-1654225-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR ANTAGONISTS | Amgen, Inc. (US) | 2006-05-10 | — | — | EP | claimed |
| US-20050256161-A1 | Melanin concentrating hormone receptor antagonists | AMGEN INC. | 2005-11-17 | — | — | US | claimed |
| WO-2005019240-A2 | MELANIN CONCENTRATING HORMONE RECEPTOR ANTAGONISTS | AMGEN, INC. (US) | 2005-03-03 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11173146-B2 | Selective activators of the intermediate conductance CA2+activated K+ channel KCa3.1 and their methods of use | KCNN3, KCNN1, KCNN2 | SLC6A4 856/4885DRD2 3347/4885KDM1A 835/4885 |
| US-20050256161-A1 | Melanin concentrating hormone receptor antagonists | MCHR1, MC1R, NPY1R | SLC6A4 158/4885DRD2 182/4885KDM1A 2300/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.