Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.63 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | ANPEP | P15144 | 1/20 | 0.60 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.59 |
| ▸ | TGM2 | P21980 | 1/20 | 0.59 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.58 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.58 |
| ▸ | DPP4 | P27487 | 1/20 | 0.58 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | CPB1 | P15086 | 1/20 | 0.57 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.57 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.56 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.56 |
| ▸ | MMP2 | P08253 | 1/20 | 0.56 |
| ▸ | MMP9 | P14780 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15177629 | 1.00 | DPP8 (0.63) | DPP8DPP7HTTANPEPFOLH1 | |
| SCHEMBL13480421 | 0.96 | HTT (0.63) | DPP8DPP7HTTANPEPFOLH1 | |
| SCHEMBL966186 | 0.91 | HTT (0.55) | DPP8DPP7HTTANPEPFOLH1 | |
| SCHEMBL19754816 | 0.90 | SLC1A3 (0.66) | DPP8DPP7HTTANPEPTGM2 | |
| Hydrochloric Acid SCHEMBL28665675 | 0.89 | SLC1A3 (0.64) | DPP8DPP7HTTANPEPTGM2 | |
| SCHEMBL13251388 | 0.89 | HTT (0.65) | DPP8DPP7HTTANPEPFOLH1 | |
| SCHEMBL19976515 | 0.88 | TGM2 (0.64) | DPP8DPP7HTTANPEPFOLH1 | |
| SCHEMBL10917494 | 0.87 | DPP8 (0.64) | DPP8DPP7HTTANPEPFOLH1 | |
| SCHEMBL23542526 | 0.87 | DPP8 (0.64) | DPP8DPP7HTTANPEPFOLH1 | |
| SCHEMBL14194799 | 0.87 | HTT (0.59) | DPP8DPP7HTTANPEPFOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240279233-A1 | MACROCYCLIC TAK1 INHIBITORS | AQILION AB (SE) | 2024-08-22 | — | — | US | disclosed |
| EP-4363422-A1 | MACROCYCLIC TAK1 INHIBITORS | Aqilion AB (SE) | 2024-05-08 | — | — | EP | disclosed |
| WO-2023275199-A1 | MACROCYCLIC TAK1 INHIBITORS | AQILION AB (SE) | 2023-01-05 | — | — | WO | disclosed |
| WO-2023275199-A1 | MACROCYCLIC TAK1 INHIBITORS | AQILION AB (SE) | 2023-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240279233-A1 | MACROCYCLIC TAK1 INHIBITORS | TAB1, TBK1, IRAK3 | DPP8 3601/4885DPP7 3815/4885HTT 2383/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.