Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 4/20 | 0.41 |
| ▸ | CCND1 | P24385 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | CASP5 | P51878 | 2/20 | 0.41 |
| ▸ | PIM1 | P11309 | 5/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 5/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30162131 | 1.00 | CDK4 (0.41) | CDK4CCND1CASP1CASP5PIM1 | |
| SCHEMBL24851328 | 0.91 | CASP1 (0.46) | CDK4CASP1CASP5PIM1PIM3 | |
| SCHEMBL30161962 | 0.91 | CASP1 (0.46) | CDK4CASP1CASP5PIM1PIM3 | |
| SCHEMBL24851149 | 0.83 | PIM1 (0.47) | PIM1PIM3PIM2ALDH1A1 | |
| SCHEMBL24851285 | 0.83 | PIM1 (0.45) | CASP1CASP5PIM1PIM3PIM2 | |
| SCHEMBL30161933 | 0.82 | CDK4 (0.45) | CDK4CCND1CASP1CASP5PIM1 | |
| SCHEMBL24851155 | 0.82 | CDK4 (0.45) | CDK4CCND1CASP1CASP5PIM1 | |
| SCHEMBL30162044 | 0.81 | CDK4 (0.49) | CDK4CCND1CASP1CASP5PIM1 | |
| SCHEMBL24851179 | 0.81 | CDK4 (0.49) | CDK4CCND1CASP1CASP5PIM1 | |
| SCHEMBL24852386 | 0.80 | CHRM2 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023278483-A1 | COMPOUNDS HAVING 1H-PYRAZOLO[4,3-C]PYRIDIN-6-AMINOS AS THERAPEUTIC AGENTS | LOMOND THERAPEUTICS, INC. (US) | 2023-01-05 | — | — | WO | disclosed |