⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12228048 | 0.74 | CRBN (0.35) | — | |
| SCHEMBL16498173 | 0.72 | — | — | |
| SCHEMBL761689 | 0.72 | — | — | |
| SCHEMBL24782527 | 0.72 | — | — | |
| SCHEMBL27390148 | 0.72 | LTA4H (0.33) | — | |
| SCHEMBL24818589 | 0.72 | PER2 (0.38) | — | |
| SCHEMBL21584983 | 0.70 | GRIN1 (0.35) | — | |
| SCHEMBL24852589 | 0.70 | — | — | |
| SCHEMBL8998692 | 0.70 | GRIN1 (0.37) | — | |
| SCHEMBL11604477 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230346951-A1 | MOLECULAR DEGRADERS OF EXTRACELLULAR PROTEINS | YALE UNIVERSITY | 2023-11-02 | — | — | US | disclosed |
| US-20230346951-A1 | MOLECULAR DEGRADERS OF EXTRACELLULAR PROTEINS | YALE UNIVERSITY | 2023-11-02 | — | — | US | disclosed |
| WO-2023028338-A2 | MANNOSE 6-PHOSPHATE OR ASGPR RECEPTOR BINDING COMPOUNDS FOR THE DEGRADATION OF EXTRACELLULAR PROTEINS | AVILAR THERAPEUTICS, INC. (US) | 2023-03-02 | — | — | WO | disclosed |
| WO-2023278222-A1 | IL4I1 INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME LLC (US) | 2023-01-05 | — | — | WO | disclosed |
| CN-108123175-B | Synthesis method of amide compound, amide compound and non-aqueous electrolyte | 微宏动力系统（湖州）有限公司 | 2020-05-22 | — | — | CN | disclosed |