Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 3/20 | 0.46 |
| ▸ | IL4I1 | Q96RQ9 | 5/20 | 0.43 |
| ▸ | EGFR | P00533 | 6/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.41 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24852000 | 0.85 | EGFR (0.55) | GUSBIL4I1EGFRERBB2PIP4K2A | |
| SCHEMBL24852005 | 0.82 | GUSB (0.47) | GUSBIL4I1EGFRERBB2PIP4K2A | |
| SCHEMBL24852013 | 0.79 | GUSB (0.48) | GUSBIL4I1EGFRERBB2PIP4K2A | |
| SCHEMBL24852500 | 0.78 | GUSB (0.44) | GUSBIL4I1EGFRERBB2KDM4E | |
| SCHEMBL24852002 | 0.77 | IL4I1 (0.44) | GUSBIL4I1EGFRERBB2KDM4E | |
| SCHEMBL24851794 | 0.77 | GUSB (0.47) | GUSBIL4I1EGFRERBB2PIP4K2A | |
| SCHEMBL24851999 | 0.77 | GUSB (0.56) | GUSBIL4I1EGFRERBB2KDM4E | |
| SCHEMBL24851914 | 0.76 | IDO1 (0.48) | GUSBIL4I1EGFRKDM4EALDH1A1 | |
| SCHEMBL24851962 | 0.76 | IL4I1 (0.51) | IL4I1EGFRERBB2MAPTKDM4E | |
| SCHEMBL24852507 | 0.76 | IL4I1 (0.51) | IL4I1EGFRKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023278222-A1 | IL4I1 INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME LLC (US) | 2023-01-05 | — | — | WO | disclosed |