Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 3/20 | 0.48 |
| ▸ | EGFR | P00533 | 6/20 | 0.45 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.44 |
| ▸ | IL4I1 | Q96RQ9 | 3/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.43 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | QPCT | Q16769 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24851794 | 0.90 | GUSB (0.47) | GUSBEGFRPIP4K2AIL4I1ERBB2 | |
| SCHEMBL24852000 | 0.88 | EGFR (0.55) | GUSBEGFRPIP4K2AIL4I1ERBB2 | |
| SCHEMBL24851913 | 0.81 | GUSB (0.43) | GUSBEGFRIL4I1ERBB2KDM4E | |
| SCHEMBL24852005 | 0.80 | GUSB (0.47) | GUSBEGFRPIP4K2AIL4I1ERBB2 | |
| SCHEMBL24851999 | 0.79 | GUSB (0.56) | GUSBEGFRIL4I1ERBB2KDM4E | |
| SCHEMBL24851924 | 0.79 | GUSB (0.46) | GUSBEGFRPIP4K2AIL4I1ERBB2 | |
| SCHEMBL24852008 | 0.76 | GUSB (0.51) | GUSBEGFRIL4I1ERBB2KDM4E | |
| SCHEMBL24851962 | 0.76 | IL4I1 (0.51) | EGFRIL4I1ERBB2KDM4EALDH1A1 | |
| SCHEMBL24852507 | 0.76 | IL4I1 (0.51) | EGFRIL4I1KDM4EALDH1A1CYP1A2 | |
| SCHEMBL20508334 | 0.76 | KDM4E (0.51) | GUSBPIP4K2ASUCNR1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023278222-A1 | IL4I1 INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME LLC (US) | 2023-01-05 | — | — | WO | disclosed |