Trifluoroacetic Acid

Trifluoroacetic Acid

SCHEMBL2485341

COC(=O)CN.O=C(O)C(F)(F)F

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.43
LMNA P02545 1/20 0.43
MGAM O43451 1/20 0.42
GAA P10253 1/20 0.42
SI P14410 1/20 0.42
MGAM2 Q2M2H8 1/20 0.42
TSHR P16473 4/20 0.40
HSD17B10 Q99714 1/20 0.37
TET2 Q6N021 1/20 0.35
RECQL P46063 1/20 0.34
GLRA1 P23415 1/20 0.33
SLC6A9 P48067 1/20 0.33
OR51E2 Q9H255 1/20 0.33
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
SLC1A1 P43005 1/20 0.32
ALDH1A1 P00352 1/20 0.32
MAPT P10636 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bicarbonate SCHEMBL27949760 0.83 MGAM (0.52) KDM4ELMNAMGAMGAASI
SCHEMBL13169650 0.83
SCHEMBL2148 0.83
SCHEMBL12140935 0.83
Acetic Acid SCHEMBL7017383 0.80 MGAM (0.57) KDM4ELMNAMGAMGAASI
Acetic Acid SCHEMBL27471902 0.80 MGAM (0.57) KDM4ELMNAMGAMGAASI
Glycine SCHEMBL3455209 0.80 GLRA1 (0.56) KDM4ELMNAMGAMGAASI
Oxalic Acid SCHEMBL30540157 0.80 LMNA (0.50) KDM4ELMNAMGAMGAASI
Acetic Acid SCHEMBL19468 0.80 MGAM (0.57) KDM4ELMNAMGAMGAASI
SCHEMBL4649402 0.80

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9227995-B2 Peptides Jacobsen, Øyvind (NO) 2016-01-05 US disclosed
CN-104507899-A Phenol derivative, preparation method and medical application thereof SICHUAN HAISCO PHARMACEUTICAL CO LTD 2015-04-08 CN disclosed
US-8710008-B2 Compounds, compositions and use UNIVERSITETET I OSLO (NO) 2014-04-29 US disclosed
US-20120245094-A1 COMPOUNDS, COMPOSITIONS AND USE UNIVERSITETET I OLSO (NO) 2012-09-27 US disclosed
US-20110263479-A1 Peptides UNIVERSITETET I OSLO (NO) 2011-10-27 US disclosed
EP-2379589-A2 COMPOUNDS, COMPOSITIONS AND USE Universitetet I Oslo (NO) 2011-10-26 EP disclosed
WO-2010073009-A2 COMPOUNDS, COMPOSITIONS AND USE UNIVERSITETET I OSLO (NO) 2010-07-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120245094-A1 COMPOUNDS, COMPOSITIONS AND USE VIP, C9, NGLY1 KDM4E 4528/4885LMNA 446/4885MGAM 4272/4885
US-20110263479-A1 Peptides VIP, NGLY1, NPPA KDM4E 4632/4885LMNA 2903/4885MGAM 3667/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.