Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 14/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10446487 | 0.82 | ALDH1A1 (0.47) | ALDH1A1GAAPARP1ACHE | |
| SCHEMBL31750298 | 0.78 | ALDH1A1 (0.50) | ALDH1A1GAAPARP1CDC7 | |
| SCHEMBL13189674 | 0.78 | ALDH1A1 (0.50) | ALDH1A1GAAPARP1 | |
| SCHEMBL13589774 | 0.78 | ALDH1A1 (0.50) | ALDH1A1GAAPARP1CDC7 | |
| SCHEMBL20100521 | 0.78 | ALDH1A1 (0.50) | ALDH1A1GAAPARP1CDC7 | |
| SCHEMBL13589780 | 0.78 | ALDH1A1 (0.50) | ALDH1A1GAAPARP1 | |
| SCHEMBL20100593 | 0.77 | ALDH1A1 (0.46) | ALDH1A1GAAPARP1 | |
| SCHEMBL30731345 | 0.74 | ALDH1A1 (0.46) | ALDH1A1GAAPARP1 | |
| SCHEMBL20100677 | 0.74 | ALDH1A1 (0.43) | ALDH1A1GAAPARP1 | |
| SCHEMBL20100561 | 0.73 | PARP1 (0.56) | ALDH1A1GAAPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8981092-B2 | Substituted 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-ones as modulators of protein kinase activity | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-03-17 | — | — | US | disclosed |
| US-20130137696-A1 | 3,4-DIHYDRO-2H-PYRROLO[1,2-A]PYRAZIN-1-ONE DERIVATIVES FOR THE MODULATION OF THE ACTIVITY OF PROTEIN KINASES | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-05-30 | — | — | US | disclosed |
| US-8394802-B2 | 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-one derivatives for the modulation of the activity of protein kinases | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-03-12 | — | — | US | disclosed |
| EP-2376492-A1 | 3,4 DIHYDRO-2H-PYRROLO[1,2-a]PYRAZIN-1-ONE DERIVATIVES | Nerviano Medical Sciences S.r.l. (IT) | 2011-10-19 | — | — | EP | disclosed |
| US-20110251179-A1 | 3,4-DIHYDRO-2H-PYRROLO[1,2-a]PYRAZIN-1-ONE DERIVATIVES | NERVIANO MEDICAL SCIENCES S.R.L (IT) | 2011-10-13 | — | — | US | disclosed |
| WO-2010031816-A1 | 3,4 DIHYDRO-2H-PYRROLO[1,2-a]PYRAZIN-1-ONE DERIVATIVES | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2010-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110251179-A1 | 3,4-DIHYDRO-2H-PYRROLO[1,2-a]PYRAZIN-1-ONE DERIVATIVES | PDK1, PDPK1, CDK3 | ALDH1A1 1974/4885GAA 2260/4885PARP1 381/4885 |
| US-20130137696-A1 | 3,4-DIHYDRO-2H-PYRROLO[1,2-A]PYRAZIN-1-ONE DERIVATIVES FOR THE MODULATION OF THE ACTIVITY OF PROTEIN KINASES | MAP3K15, MAP3K1, MAP3K3 | ALDH1A1 2930/4885GAA 2596/4885PARP1 591/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.