Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.43 |
| ▸ | IL1B | P01584 | 8/20 | 0.41 |
| ▸ | TNF | P01375 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KRAS | P01116 | 6/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30181221 | 1.00 | NLRP3 (0.43) | NLRP3IL1BTNFKDM4EHSD17B10 | |
| SCHEMBL29180688 | 1.00 | NLRP3 (0.43) | NLRP3IL1BTNFKDM4EHSD17B10 | |
| SCHEMBL30180843 | 0.88 | NLRP3 (0.40) | NLRP3IL1BTNFKDM4E | |
| SCHEMBL24855763 | 0.88 | NLRP3 (0.40) | NLRP3IL1BTNFKDM4E | |
| SCHEMBL24855380 | 0.86 | NLRP3 (0.40) | NLRP3IL1BTNFKDM4E | |
| SCHEMBL30181079 | 0.86 | NLRP3 (0.40) | NLRP3IL1BTNFKDM4E | |
| SCHEMBL24574798 | 0.84 | IL1B (0.57) | NLRP3IL1BTNF | |
| SCHEMBL31280946 | 0.84 | IL1B (0.57) | NLRP3IL1BTNF | |
| SCHEMBL30488566 | 0.84 | NLRP3 (0.40) | NLRP3IL1BTNFKDM4EHSD17B10 | |
| SCHEMBL26434881 | 0.80 | IL1B (0.49) | NLRP3IL1BTNFKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023275366-A1 | NLRP3 INFLAMMASOME INHIBITORS | ASTRAZENECA AB (SE) | 2023-01-05 | — | — | WO | disclosed |