Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.40 |
| ▸ | IL1B | P01584 | 8/20 | 0.38 |
| ▸ | TNF | P01375 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MPI | P34949 | 1/20 | 0.37 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.34 |
| ▸ | SMO | Q99835 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24855380 | 1.00 | NLRP3 (0.40) | NLRP3IL1BTNFKDM4EL3MBTL1 | |
| SCHEMBL29180688 | 0.86 | NLRP3 (0.43) | NLRP3IL1BTNFKDM4E | |
| SCHEMBL30181221 | 0.86 | NLRP3 (0.43) | NLRP3IL1BTNFKDM4E | |
| SCHEMBL24855484 | 0.86 | NLRP3 (0.43) | NLRP3IL1BTNFKDM4E | |
| SCHEMBL26435326 | 0.82 | IL1B (0.46) | NLRP3IL1BTNFKDM4EL3MBTL1 | |
| SCHEMBL30180843 | 0.82 | NLRP3 (0.40) | NLRP3IL1BTNFKDM4ESMO | |
| SCHEMBL24855763 | 0.82 | NLRP3 (0.40) | NLRP3IL1BTNFKDM4ESMO | |
| SCHEMBL26435667 | 0.81 | IL1B (0.48) | NLRP3IL1BTNFKDM4EL3MBTL1 | |
| SCHEMBL26435640 | 0.81 | IL1B (0.61) | NLRP3IL1BTNF | |
| SCHEMBL26435361 | 0.80 | NLRP3 (0.46) | NLRP3IL1BTNFKDM4EKAT2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4363406-A1 | NLRP3 INFLAMMASOME INHIBITORS | Astrazeneca AB (SE) | 2024-05-08 | — | — | EP | claimed |
| CN-117580826-A | NLRP3 inflammation corpuscle inhibitor | 阿斯利康(瑞典)有限公司 | 2024-02-20 | — | — | CN | claimed |
| WO-2023275366-A1 | NLRP3 INFLAMMASOME INHIBITORS | ASTRAZENECA AB (SE) | 2023-01-05 | — | — | WO | claimed |
| EP-4363406-A1 | NLRP3 INFLAMMASOME INHIBITORS | Astrazeneca AB (SE) | 2024-05-08 | — | — | EP | disclosed |
| CN-117580826-A | NLRP3 inflammation corpuscle inhibitor | 阿斯利康(瑞典)有限公司 | 2024-02-20 | — | — | CN | disclosed |
| WO-2023275366-A1 | NLRP3 INFLAMMASOME INHIBITORS | ASTRAZENECA AB (SE) | 2023-01-05 | — | — | WO | disclosed |