Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2485805 | 1.00 | USP30 (0.54) | USP30NPC1KMT2AMEN1LMNA | |
| SCHEMBL2486141 | 0.87 | LMNA (0.52) | USP30KMT2AMEN1LMNAKDM4E | |
| SCHEMBL1752680 | 0.79 | NPC1 (0.74) | USP30NPC1KMT2AMEN1LMNA | |
| SCHEMBL17765418 | 0.79 | NPC1 (0.74) | USP30NPC1KMT2AMEN1LMNA | |
| SCHEMBL2389717 | 0.78 | NPC1 (0.77) | USP30NPC1KMT2AMEN1LMNA | |
| SCHEMBL2525285 | 0.78 | NPC1 (0.77) | USP30NPC1KMT2AMEN1LMNA | |
| SCHEMBL12765472 | 0.78 | USP30 (0.55) | USP30NPC1KMT2AMEN1LMNA | |
| SCHEMBL2317236 | 0.77 | L3MBTL1 (0.56) | USP30NPC1KMT2AMEN1LMNA | |
| SCHEMBL20370279 | 0.77 | USP30 (0.70) | USP30NPC1KMT2AMEN1LMNA | |
| SCHEMBL2490286 | 0.77 | L3MBTL1 (0.56) | USP30NPC1KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2559455-A1 | Heteroaryl derivatives as DGAT1 inhibitors | Novartis AG (CH) | 2013-02-20 | — | — | EP | disclosed |
| EP-2548618-A2 | Organic compounds | Novartis AG (CH) | 2013-01-23 | — | — | EP | disclosed |
| EP-2380631-A1 | Heteroaryl derivatives as DGAT1 inhibitors | Novartis AG (CH) | 2011-10-26 | — | — | EP | disclosed |