Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.47 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CCR6 | P51684 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2485805 | 0.87 | USP30 (0.54) | LMNAKDM4EALDH1A1NR4A2KMT2A | |
| SCHEMBL2485807 | 0.87 | USP30 (0.54) | LMNAKDM4EALDH1A1NR4A2KMT2A | |
| SCHEMBL2486771 | 0.76 | ADORA3 (0.57) | LMNAALDH1A1KMT2ATDP1HTT | |
| SCHEMBL2317426 | 0.75 | HCRTR2 (0.48) | LMNARIPK1CNR2HCRTR2 | |
| SCHEMBL2320681 | 0.75 | HCRTR2 (0.48) | LMNARIPK1CNR2HCRTR2 | |
| SCHEMBL2488297 | 0.72 | ADORA3 (0.49) | LMNAALDH1A1POLBCNR2USP30 | |
| SCHEMBL13571486 | 0.71 | ALDH1A1 (0.45) | LMNAALDH1A1HTTPOLBCYP2C9 | |
| SCHEMBL28471497 | 0.70 | CYP2C9 (0.54) | LMNAKDM4EALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL2176361 | 0.69 | F2 (0.50) | LMNAKDM4EALDH1A1HTTPOLB | |
| SCHEMBL12491697 | 0.69 | F2 (0.50) | LMNAKDM4EALDH1A1HTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2548618-A2 | Organic compounds | Novartis AG (CH) | 2013-01-23 | — | — | EP | disclosed |
| EP-2380631-A1 | Heteroaryl derivatives as DGAT1 inhibitors | Novartis AG (CH) | 2011-10-26 | — | — | EP | disclosed |
| EP-2380631-A1 | Heteroaryl derivatives as DGAT1 inhibitors | Novartis AG (CH) | 2011-10-26 | — | — | EP | disclosed |