Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.69 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.43 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.41 |
| ▸ | PGR | P06401 | 2/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.41 |
| ▸ | AR | P10275 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5607024 | 0.82 | L3MBTL1 (1.00) | L3MBTL1KEAP1NFE2L2POLBPLA2G7 | |
| SCHEMBL2642570 | 0.78 | KEAP1 (0.53) | L3MBTL1KEAP1NFE2L2PLA2G7GLO1 | |
| SCHEMBL27275056 | 0.77 | KEAP1 (0.52) | L3MBTL1KEAP1NFE2L2GLO1NR3C1 | |
| SCHEMBL10094332 | 0.76 | L3MBTL1 (0.74) | L3MBTL1KEAP1NFE2L2POLBPLA2G7 | |
| SCHEMBL2737238 | 0.76 | L3MBTL1 (0.54) | L3MBTL1POLBKDM4EKMT2A | |
| SCHEMBL11234113 | 0.76 | L3MBTL1 (0.63) | L3MBTL1KEAP1POLBKMT2A | |
| SCHEMBL19541652 | 0.76 | GABRA1 (0.41) | L3MBTL1POLBKDM4EALDH1A1HPGD | |
| SCHEMBL21870755 | 0.75 | KEAP1 (0.50) | L3MBTL1KEAP1NFE2L2PLA2G7GLO1 | |
| SCHEMBL2642445 | 0.75 | KEAP1 (0.50) | L3MBTL1KEAP1NFE2L2GLO1NR3C1 | |
| SCHEMBL26386536 | 0.75 | KEAP1 (0.50) | L3MBTL1KEAP1NFE2L2PLA2G7GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230002355-A1 | COMPOUND AS SHP2 INHIBITOR AND USE THEREOF | NANJING SANHOME PHARMACEUTICAL CO., LTD. (CN) | 2023-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230002355-A1 | COMPOUND AS SHP2 INHIBITOR AND USE THEREOF | PTPN1, PTPN5, PTPN7 | L3MBTL1 3173/4885KEAP1 695/4885NFE2L2 3226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.