Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 5/20 | 0.53 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | TOP1 | P11387 | 2/20 | 0.33 |
| ▸ | ACLY | P53396 | 2/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2487909 | 0.90 | CHRM1 (0.43) | CHRM1P2RX7 | |
| SCHEMBL2492208 | 0.88 | CHRM1 (0.41) | CHRM1CHRM5PTGDR2 | |
| SCHEMBL2488348 | 0.87 | CHRM1 (0.40) | CHRM1 | |
| SCHEMBL2492205 | 0.87 | CHRM1 (0.41) | CHRM1PTGDR2 | |
| SCHEMBL2486079 | 0.87 | CHRM1 (0.70) | CHRM1MAPTTP53TOP1 | |
| SCHEMBL2488682 | 0.87 | CHRM1 (0.57) | CHRM1CHRM5MAPTBDKRB1TP53 | |
| SCHEMBL2488465 | 0.86 | CHRM1 (0.41) | CHRM1HTR2CHTR2BPTGDR2P2RX7 | |
| SCHEMBL2488979 | 0.86 | CHRM1 (0.39) | CHRM1MAPTTP53P2RX7 | |
| SCHEMBL2487590 | 0.85 | S1PR1 (0.42) | CHRM1S1PR1 | |
| SCHEMBL2491881 | 0.84 | ERN1 (0.42) | CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037739-B1 | BENZYL-SUBSTITUTED QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2011-10-26 | — | — | EP | claimed |