SCHEMBL24865619

SCHEMBL24865619

CN1C(=O)NCc2cc(Nc3ccc(N4CCC(C(F)(F)F)CC4)cc3)ccc21

nearest known ligand 0.36

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
BCL6 P41182 1/20 0.36
EGFR P00533 3/20 0.35
SYK P43405 2/20 0.35
CNR2 P34972 1/20 0.34
SCN10A Q9Y5Y9 1/20 0.34
DCLK1 O15075 1/20 0.34
LRRK2 Q5S007 1/20 0.34
MGLL Q99685 1/20 0.34
JAK2 O60674 1/20 0.34
MAPK10 P53779 1/20 0.33
TNK2 Q07912 1/20 0.33
MAPT P10636 1/20 0.33
HPGD P15428 1/20 0.33
MAPKAPK2 P49137 1/20 0.32
PTGES O14684 1/20 0.32
BRD4 O60885 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24865338 0.84 TRIM24 (0.42) BCL6EGFRSYKCNR2JAK2
SCHEMBL24865600 0.83 BRD4 (0.45) BCL6EGFRSYKCNR2SCN10A
SCHEMBL31123328 0.83 BRD4 (0.45) BCL6EGFRSYKCNR2SCN10A
SCHEMBL24865354 0.82 CNR2 (0.36) BCL6EGFRSYKCNR2SCN10A
SCHEMBL31123249 0.82 CNR2 (0.36) BCL6EGFRSYKCNR2SCN10A
SCHEMBL30336523 0.82 MKNK1 (0.44) CNR2MAPK10
SCHEMBL24865524 0.82 MKNK1 (0.44) CNR2MAPK10
SCHEMBL24865665 0.79 APP (0.54) BCL6SYKCNR2DCLK1LRRK2
SCHEMBL24865525 0.78 BCL6 (0.35) BCL6EGFRSYKCNR2SCN10A
SCHEMBL24865678 0.78 BCL6 (0.40) BCL6EGFRSYKCNR2MGLL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240327393-A1 FERROPTOSIS MODULATORS, PREPARATIONS, AND USES THEREOF Sironax Ltd. (KY) 2024-10-03 US disclosed
CN-117999259-A Iron death modulators, their preparation and use 维泰瑞隆有限公司 2024-05-07 CN disclosed
WO-2023280296-A1 FERROPTOSIS MODULATORS, PREPARATIONS, AND USES THEREOF Sironax Ltd. (KY) 2023-01-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240327393-A1 FERROPTOSIS MODULATORS, PREPARATIONS, AND USES THEREOF AIFM2, GPX1, GPX4 BCL6 390/4885EGFR 3634/4885SYK 4597/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.