Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 5/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.38 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.38 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.38 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24867214 | 0.81 | RAB9A (0.43) | SMN1; SMN2RAB9APTGS1PTGS2LMNA | |
| SCHEMBL24867240 | 0.80 | BRAF (0.42) | RAB9AMEN1KMT2AMAPK1 | |
| SCHEMBL24867213 | 0.79 | TSHR (0.42) | POLBALDH1A1RAB9ALMNAHPGD | |
| SCHEMBL24866873 | 0.78 | S1PR1 (0.42) | RAB9AMAPK1 | |
| SCHEMBL24867486 | 0.78 | RAB9A (0.44) | RAB9AMEN1KMT2AMAPK1 | |
| SCHEMBL24867211 | 0.77 | SCN9A (0.45) | RAB9AMAPK1 | |
| SCHEMBL24867210 | 0.76 | RAB9A (0.37) | RAB9AMAPK1 | |
| SCHEMBL24867190 | 0.76 | RAB9A (0.47) | KDM4ETP53SMN1; SMN2POLBALDH1A1 | |
| SCHEMBL24867174 | 0.76 | GAA (0.49) | KDM4ETP53SMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL30130213 | 0.74 | SYK (0.40) | RAB9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023283488-A9 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CZ BIOHUB SF, LLC (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023283488-A2 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CHAN ZUCKERBERG BIOHUB, INC. (US) | 2023-01-12 | — | — | WO | disclosed |