Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24866920 | 0.87 | FLT3 (0.39) | FLT3TYRO3MERTKGAS6PIK3CD | |
| SCHEMBL24866931 | 0.83 | AOC3 (0.38) | PIK3CDPIK3C3GBA1MAPK1AOC3 | |
| SCHEMBL24867275 | 0.80 | MAPK8 (0.41) | FLT3TYRO3MERTKGAS6PIK3CD | |
| SCHEMBL24866919 | 0.76 | FLT3 (0.38) | FLT3TYRO3MERTKGAS6PIK3CD | |
| SCHEMBL24866922 | 0.73 | MAPK1 (0.36) | FLT3PIK3CDPIK3C3MAPK1AOC3 | |
| SCHEMBL24867207 | 0.68 | SCN5A (0.46) | PIK3CDPIK3C3PIK3CAPIK3CGACVRL1 | |
| SCHEMBL24867227 | 0.66 | KCNH2 (0.41) | ACVRL1PTK2 | |
| SCHEMBL24867177 | 0.65 | PIK3C3 (0.48) | FLT3TYRO3MERTKGAS6PIK3CD | |
| SCHEMBL14611010 | 0.65 | MAPK1 (0.50) | TYRO3MERTKPIK3CDPIK3C3PIK3CA | |
| SCHEMBL24867246 | 0.64 | AURKA (0.53) | MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023283488-A9 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CZ BIOHUB SF, LLC (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023283488-A2 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CHAN ZUCKERBERG BIOHUB, INC. (US) | 2023-01-12 | — | — | WO | disclosed |