Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.37 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 4/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24867275 | 0.86 | MAPK8 (0.41) | FLT3TYRO3MERTKGAS6PIK3CD | |
| SCHEMBL24867273 | 0.85 | AOC3 (0.36) | PIM1LRRK2DEGS1ACACBMAPK8 | |
| SCHEMBL24867264 | 0.85 | AOC3 (0.36) | PIM1LRRK2DEGS1ACACBMAPK8 | |
| SCHEMBL24866932 | 0.76 | FLT3 (0.38) | FLT3TYRO3MERTKGAS6ROCK1 | |
| SCHEMBL24866920 | 0.75 | FLT3 (0.39) | FLT3TYRO3MERTKGAS6ROCK1 | |
| SCHEMBL24867267 | 0.71 | DYRK1A (0.41) | MAPK8MAPK9AOC3MAPK1 | |
| SCHEMBL3046596 | 0.66 | MKNK1 (0.69) | PIM1 | |
| SCHEMBL14494692 | 0.65 | HRH3 (0.58) | MERTKPIM1DEGS1 | |
| SCHEMBL14611010 | 0.65 | MAPK1 (0.50) | TYRO3MERTKACACBPIK3CDPIK3C3 | |
| SCHEMBL24867207 | 0.64 | SCN5A (0.46) | PIK3CDPIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023283488-A9 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CZ BIOHUB SF, LLC (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023283488-A2 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CHAN ZUCKERBERG BIOHUB, INC. (US) | 2023-01-12 | — | — | WO | disclosed |