Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 3/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | ULK1 | O75385 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24866922 | 0.90 | MAPK1 (0.36) | AOC3MAPK1PTGS1CCNA2CDK2 | |
| SCHEMBL24867263 | 0.84 | MAPK1 (0.56) | AOC3MAPK1MAPK8MAPK9MAPK10 | |
| SCHEMBL24866932 | 0.83 | FLT3 (0.38) | AOC3GBA1MAPK1CDK4ALDH1A1 | |
| SCHEMBL24867261 | 0.83 | MAP4K1 (0.42) | AOC3CDK4CCNA2CDK2 | |
| SCHEMBL24867267 | 0.82 | DYRK1A (0.41) | AOC3GBA1MAPK1ULK1MAPK8 | |
| SCHEMBL24867264 | 0.79 | AOC3 (0.36) | AOC3MAPK1PTGS1ULK1MAPK8 | |
| SCHEMBL24867273 | 0.79 | AOC3 (0.36) | AOC3MAPK1PTGS1ULK1MAPK8 | |
| SCHEMBL24867265 | 0.78 | ROCK2 (0.53) | AOC3 | |
| SCHEMBL24866850 | 0.72 | MAP4K1 (0.45) | PTGS1CCNA2CDK2PTGS2KCNH2 | |
| SCHEMBL24866920 | 0.71 | FLT3 (0.39) | AOC3MAPK1IRAK4ULK1IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023283488-A9 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CZ BIOHUB SF, LLC (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023283488-A2 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CHAN ZUCKERBERG BIOHUB, INC. (US) | 2023-01-12 | — | — | WO | disclosed |