SCHEMBL24867209

SCHEMBL24867209

CC(C)Cc1ccc(Nc2ncc(Nc3ccncc3C#Cc3ccccc3)cn2)cc1

nearest known ligand 0.41

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ACACB O00763 18/20 0.41
GRM5 P41594 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24866865 0.84 CDK1 (0.39)
SCHEMBL24867298 0.78 PTGS1 (0.38)
SCHEMBL24867304 0.78 RAB9A (0.40)
SCHEMBL24867214 0.77 RAB9A (0.43) ACACB
SCHEMBL24867297 0.77 PTGS1 (0.45) ACACB
SCHEMBL24867187 0.76 ACACB (0.38) ACACB
SCHEMBL24867215 0.75 PTGS1 (0.41)
SCHEMBL24866885 0.74 RAB9A (0.52) ACACB
SCHEMBL30130169 0.74 RAB9A (0.52) ACACB
SCHEMBL24867268 0.72 CHEK1 (0.49)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023283488-A9 CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF CZ BIOHUB SF, LLC (US) 2023-05-25 WO disclosed
WO-2023283488-A2 CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF CHAN ZUCKERBERG BIOHUB, INC. (US) 2023-01-12 WO disclosed