Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | WEE1 | P30291 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24867251 | 0.99 | CHEK1 (0.39) | NPY5RCHEK1CDK2KDRKCNH2 | |
| SCHEMBL24867241 | 0.98 | CHEK1 (0.38) | NPY5RCHEK1CDK2KDRKCNH2 | |
| SCHEMBL24867271 | 0.91 | SYK (0.40) | CHEK1CDK2KCNH2SCN5ASCN9A | |
| SCHEMBL24867250 | 0.90 | CHEK1 (0.36) | CHEK1CDK2KDRKCNH2SCN5A | |
| SCHEMBL24866856 | 0.82 | MAP4K1 (0.45) | NPY5RKCNH2SCN5ASCN9ANAMPT | |
| SCHEMBL24867301 | 0.82 | PDE4A (0.38) | CHEK1CDK2KDRHDAC3CDK9 | |
| SCHEMBL24867299 | 0.81 | PDE4A (0.39) | CHEK1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL24867150 | 0.81 | NAMPT (0.40) | NPY5RKDRNAMPTLMNATSHR | |
| SCHEMBL24866850 | 0.79 | MAP4K1 (0.45) | NPY5RCDK2KCNH2SCN5ASCN9A | |
| SCHEMBL24867227 | 0.78 | KCNH2 (0.41) | NPY5RKCNH2SCN5ASCN9ANAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023283488-A9 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CZ BIOHUB SF, LLC (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023283488-A2 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CHAN ZUCKERBERG BIOHUB, INC. (US) | 2023-01-12 | — | — | WO | disclosed |