Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 14/20 | 0.39 |
| ▸ | ACACB | O00763 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | NPR3 | P17342 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24867301 | 0.99 | PDE4A (0.38) | PDE4AACACBPDE4DPDE4BPDE4C | |
| SCHEMBL24867294 | 0.90 | CHEK1 (0.49) | CHEK1 | |
| SCHEMBL24867187 | 0.85 | ACACB (0.38) | ACACB | |
| SCHEMBL24867218 | 0.84 | OPRM1 (0.32) | — | |
| SCHEMBL24866872 | 0.84 | PTGS1 (0.45) | ACACB | |
| SCHEMBL24866869 | 0.83 | PDE4A (0.42) | PDE4AACACBADRB1ADRB3 | |
| SCHEMBL24867251 | 0.81 | CHEK1 (0.39) | PDE4APDE4DPDE4BPDE4CCHEK1 | |
| SCHEMBL24867253 | 0.81 | NPY5R (0.38) | PDE4APDE4DPDE4BPDE4CCHEK1 | |
| SCHEMBL24866867 | 0.81 | PTGS1 (0.36) | ACACB | |
| SCHEMBL24867241 | 0.81 | CHEK1 (0.38) | PDE4APDE4DPDE4BPDE4CCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023283488-A9 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CZ BIOHUB SF, LLC (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023283488-A2 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CHAN ZUCKERBERG BIOHUB, INC. (US) | 2023-01-12 | — | — | WO | disclosed |