Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 5/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24867251 | 0.92 | CHEK1 (0.39) | CHEK1CDK1CDK4CCNB1CCND1 | |
| SCHEMBL24867253 | 0.91 | NPY5R (0.38) | CHEK1CDK4CCND1CDK2KCNH2 | |
| SCHEMBL24867241 | 0.91 | CHEK1 (0.38) | CHEK1CDK1CDK4CCNB1CCND1 | |
| SCHEMBL24867250 | 0.91 | CHEK1 (0.36) | TBK1CHEK1CDK1CDK4CCNB1 | |
| SCHEMBL24867279 | 0.83 | SYK (0.45) | SYKTBK1KDM4CNAMPTHDAC3 | |
| SCHEMBL24867266 | 0.79 | PTK2 (0.39) | SYKLRRK2 | |
| SCHEMBL24867299 | 0.77 | PDE4A (0.39) | CHEK1 | |
| SCHEMBL24867301 | 0.76 | PDE4A (0.38) | CHEK1CDK2HDAC3CDK9HDAC6 | |
| SCHEMBL24867144 | 0.76 | ABL1 (0.38) | SYKCHEK1CDK1CDK2 | |
| SCHEMBL24866856 | 0.74 | MAP4K1 (0.45) | KCNH2SCN5ASCN9ANAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023283488-A9 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CZ BIOHUB SF, LLC (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023283488-A2 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CHAN ZUCKERBERG BIOHUB, INC. (US) | 2023-01-12 | — | — | WO | disclosed |