Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.55 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.45 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.45 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24867205 | 0.82 | SCN9A (0.54) | SCN9AKCNH2SCN5AMEN1ALOX12 | |
| SCHEMBL3653545 | 0.81 | SCN9A (0.47) | SCN9AKCNH2SCN5AMEN1ALOX12 | |
| SCHEMBL24867285 | 0.81 | MEN1 (0.54) | SCN9AKCNH2SCN5AMEN1ALOX12 | |
| SCHEMBL24867281 | 0.79 | ACACB (0.45) | SCN9A | |
| SCHEMBL7307843 | 0.77 | MAPK14 (0.51) | SCN9AKCNH2SCN5AMEN1KMT2A | |
| SCHEMBL3656271 | 0.76 | EGFR (0.47) | SCN9AKCNH2SCN5AMEN1KMT2A | |
| SCHEMBL2484865 | 0.76 | — | — | |
| SCHEMBL3656146 | 0.75 | HDAC6 (0.51) | SCN9AKCNH2SCN5AMEN1KMT2A | |
| SCHEMBL14355080 | 0.72 | CYP11B1 (0.54) | SCN9AMEN1KMT2A | |
| SCHEMBL29408378 | 0.72 | RAB9A (0.61) | MEN1ALOX12KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023283488-A9 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CZ BIOHUB SF, LLC (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023283488-A2 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CHAN ZUCKERBERG BIOHUB, INC. (US) | 2023-01-12 | — | — | WO | disclosed |