Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 7/20 | 0.37 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | BCL6 | P41182 | 2/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24867295 | 0.88 | POLB (0.38) | POLBTGFBR1NUDT1MAPK1TGFBR2 | |
| SCHEMBL24867147 | 0.85 | POLB (0.36) | POLBTGFBR1TGFBR2BCL6INSR | |
| SCHEMBL24867298 | 0.85 | PTGS1 (0.38) | TGFBR1MAPK1BCL6PTGS1PTGS2 | |
| SCHEMBL24867304 | 0.81 | RAB9A (0.40) | TGFBR1MAPK1TGFBR2PTGS1PTGS2 | |
| SCHEMBL24867270 | 0.80 | POLB (0.39) | POLBBCL6NCOR2 | |
| SCHEMBL24866871 | 0.79 | MAPK3 (0.36) | POLBMAPK1TDO2PTGS1PTGS2 | |
| SCHEMBL24867180 | 0.75 | VNN1 (0.43) | — | |
| SCHEMBL24867280 | 0.71 | SYK (0.49) | MAPK1PTGS1PTGS2NOD2 | |
| SCHEMBL24867297 | 0.71 | PTGS1 (0.45) | MAPK1PTGS1PTGS2 | |
| SCHEMBL24867214 | 0.70 | RAB9A (0.43) | TGFBR1MAPK1PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023283488-A9 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CZ BIOHUB SF, LLC (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023283488-A2 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CHAN ZUCKERBERG BIOHUB, INC. (US) | 2023-01-12 | — | — | WO | disclosed |