Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK3 | P27361 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 2/20 | 0.32 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24867295 | 0.91 | POLB (0.38) | MAPK3MAPK1ALDH1A1DHODHPTGS1 | |
| SCHEMBL24867225 | 0.87 | PTGS1 (0.43) | PTGS1PTGS2KDM4E | |
| SCHEMBL24866945 | 0.81 | SCN9A (0.34) | MAPK1RAB9ARETCCNB2CDK1 | |
| SCHEMBL24867191 | 0.80 | VNN1 (0.38) | MAPK3MAPK1RAB9AS1PR1S1PR3 | |
| SCHEMBL24867296 | 0.79 | POLB (0.37) | MAPK1TDO2DHODHPTGS1PTGS2 | |
| SCHEMBL24867178 | 0.78 | VNN1 (0.44) | MAPK1S1PR1S1PR3 | |
| SCHEMBL24867147 | 0.77 | POLB (0.36) | CDK2POLB | |
| SCHEMBL24867298 | 0.76 | PTGS1 (0.38) | MAPK1RAB9ACCNA2CDK2DHODH | |
| SCHEMBL24867304 | 0.76 | RAB9A (0.40) | MAPK1RAB9ACDK2ALDH1A1DHODH | |
| SCHEMBL24867214 | 0.74 | RAB9A (0.43) | MAPK1RAB9APTGS1PTGS2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023283488-A9 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CZ BIOHUB SF, LLC (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023283488-A2 | CDK19-SELECTIVE INHIBITORS, AND METHODS OF USE THEREOF | CHAN ZUCKERBERG BIOHUB, INC. (US) | 2023-01-12 | — | — | WO | disclosed |