Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | ALDH2 | P05091 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.31 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25302308 | 0.71 | NOTUM (0.46) | NOTUMMAP4K4MAPK13MAPK12MAPK11 | |
| SCHEMBL24196193 | 0.69 | NOTUM (0.52) | NOTUMMAP4K4MAPK13MAPK12MAPK11 | |
| SCHEMBL6042142 | 0.68 | NOTUM (0.77) | NOTUMMAP4K4MAPK13MAPK12MAPK11 | |
| SCHEMBL3901501 | 0.68 | NOTUM (0.64) | NOTUMMAP4K4HDAC6ALDH2 | |
| SCHEMBL4231200 | 0.68 | NOTUM (0.64) | NOTUMMAP4K4MAPK13MAPK12MAPK11 | |
| SCHEMBL29465044 | 0.67 | NOTUM (0.58) | NOTUMPDE3BPDE3AHDAC6BTK | |
| SCHEMBL31055668 | 0.67 | MGLL (0.48) | NOTUMMAP4K4HDAC6ALDH2MGLL | |
| SCHEMBL15781386 | 0.65 | NOTUM (0.46) | NOTUMMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL4102273 | 0.65 | MAPK14 (0.53) | NOTUMMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL3477782 | 0.65 | SCN8A (0.46) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023279986-A1 | SIX-MEMBERED ARYL OR HETEROARYL AMIDES, AND COMPOSITION AND USE THEREOF | 贝达药业股份有限公司 | 2023-01-12 | — | — | WO | disclosed |