Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | CACNA2D1 | P54289 | 4/20 | 0.44 |
| ▸ | CACNB1 | Q02641 | 4/20 | 0.44 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.44 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5461890 | 0.84 | ALDH1A1 (0.51) | ALDH1A1SLC6A9ATMCNR1CNR2 | |
| SCHEMBL85386 | 0.81 | ALDH1A1 (0.54) | ALDH1A1SLC6A9CNR1CNR2CACNA2D1 | |
| SCHEMBL3296378 | 0.80 | SLC6A9 (0.47) | ALDH1A1SLC6A9ATMCNR1CNR2 | |
| Hydrochloric Acid SCHEMBL4509686 | 0.80 | ALDH1A1 (0.50) | ALDH1A1SLC6A9ATMCNR1CNR2 | |
| SCHEMBL20594076 | 0.80 | KMT2A (0.57) | ALDH1A1SLC6A9CNR1CNR2KMT2A | |
| SCHEMBL12499368 | 0.78 | ALDH1A1 (0.51) | ALDH1A1SLC6A9CNR1CNR2CACNA2D1 | |
| SCHEMBL3299615 | 0.77 | MAOB (0.53) | ALDH1A1SLC6A9CNR1CNR2KMT2A | |
| SCHEMBL4175324 | 0.74 | KMT2A (0.49) | ALDH1A1SLC6A9CNR1CNR2CACNA2D1 | |
| SCHEMBL1366519 | 0.74 | ALDH1A1 (0.48) | ALDH1A1SLC6A9CNR1CNR2CACNA2D1 | |
| SCHEMBL72964 | 0.74 | CYP3A4 (0.49) | ALDH1A1SLC6A9CNR1CNR2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4366834-A1 | COMPOUNDS FOR TARGETING DEGRADATION OF IRAK4 PROTEINS | Biogen MA Inc. (US) | 2024-05-15 | — | — | EP | disclosed |
| WO-2023283372-A1 | COMPOUNDS FOR TARGETING DEGRADATION OF IRAK4 PROTEINS | BIOGEN MA INC. (US) | 2023-01-12 | — | — | WO | disclosed |
| WO-2023283372-A1 | COMPOUNDS FOR TARGETING DEGRADATION OF IRAK4 PROTEINS | BIOGEN MA INC. (US) | 2023-01-12 | — | — | WO | disclosed |