Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2487306 | 0.87 | LMNA (0.65) | LMNACHRM1TP53CNR2 | |
| SCHEMBL2492278 | 0.85 | CHRM1 (0.54) | CHRM1MGLL | |
| SCHEMBL2487888 | 0.85 | CHRM1 (0.52) | CHRM1MGLLTP53 | |
| SCHEMBL2490511 | 0.84 | LMNA (0.59) | LMNACHRM1TP53CNR2 | |
| SCHEMBL3234156 | 0.80 | LMNA (0.62) | LMNACHRM1TP53CNR2 | |
| SCHEMBL3237179 | 0.80 | LMNA (0.59) | LMNACHRM1TP53CNR2 | |
| SCHEMBL2489418 | 0.80 | TP53 (0.53) | LMNACHRM1TP53CNR2 | |
| SCHEMBL2490815 | 0.79 | CHRM1 (0.49) | CHRM1MGLL | |
| SCHEMBL2491002 | 0.79 | CHRM1 (0.71) | LMNACHRM1 | |
| SCHEMBL3241260 | 0.76 | TP53 (0.68) | LMNACHRM1TP53CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037739-B1 | BENZYL-SUBSTITUTED QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2011-10-26 | — | — | EP | claimed |