Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 3/20 | 0.54 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 10/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2490002 | 0.88 | CHRM1 (0.71) | CHRM1MGLL | |
| SCHEMBL2490815 | 0.87 | CHRM1 (0.49) | CHRM1MGLLPTPN1KMT2AMEN1 | |
| SCHEMBL2487888 | 0.85 | CHRM1 (0.52) | CHRM1MGLLPTPN1KMT2AMEN1 | |
| SCHEMBL2487409 | 0.85 | LMNA (0.47) | CHRM1MGLL | |
| SCHEMBL2489039 | 0.84 | CHRM1 (0.74) | CHRM1 | |
| SCHEMBL3234399 | 0.82 | CHRM1 (0.63) | CHRM1 | |
| SCHEMBL2490145 | 0.80 | CHRM1 (0.59) | CHRM1SMN1; SMN2 | |
| SCHEMBL2492203 | 0.80 | CHRM1 (0.61) | CHRM1POLBSMN1; SMN2 | |
| SCHEMBL2485661 | 0.80 | CHRM1 (0.61) | CHRM1 | |
| SCHEMBL2487941 | 0.80 | CHRM1 (0.58) | CHRM1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037739-B1 | BENZYL-SUBSTITUTED QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2011-10-26 | — | — | EP | claimed |