Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 9/20 | 0.40 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.33 |
| ▸ | PRKACA | P17612 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | CTSA | P10619 | 2/20 | 0.32 |
| ▸ | ICMT | O60725 | 1/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | PRKCG | P05129 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2487909 | 0.87 | CHRM1 (0.43) | CHRM1 | |
| SCHEMBL2492208 | 0.86 | CHRM1 (0.41) | CHRM1PTGDR2 | |
| SCHEMBL2487841 | 0.86 | CHRM1 (0.55) | CHRM1RIPK3METAP2MAP4K4PRKACA | |
| SCHEMBL2486084 | 0.84 | CHRM1 (0.53) | CHRM1BDKRB1PTGDR2 | |
| SCHEMBL2492205 | 0.83 | CHRM1 (0.41) | CHRM1ROCK2PTGDR2 | |
| SCHEMBL2488348 | 0.83 | CHRM1 (0.40) | CHRM1 | |
| SCHEMBL2487937 | 0.83 | CHRM1 (0.42) | CHRM1METAP2MAP4K4PRKACACDK2 | |
| SCHEMBL2488465 | 0.82 | CHRM1 (0.41) | CHRM1PTGDR2 | |
| SCHEMBL2487485 | 0.81 | CHRM1 (0.45) | CHRM1METAP2 | |
| SCHEMBL2491881 | 0.80 | ERN1 (0.42) | CHRM1RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037739-B1 | BENZYL-SUBSTITUTED QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2011-10-26 | — | — | EP | claimed |