Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 11/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.32 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 2/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.31 |
| ▸ | KMO | O15229 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2492205 | 0.89 | CHRM1 (0.41) | CHRM1GRIN2B | |
| SCHEMBL2486084 | 0.87 | CHRM1 (0.53) | CHRM1 | |
| SCHEMBL2492208 | 0.86 | CHRM1 (0.41) | CHRM1GRIN2B | |
| SCHEMBL2486353 | 0.85 | CHRM1 (0.57) | CHRM1CAPN1KMO | |
| SCHEMBL2487909 | 0.85 | CHRM1 (0.43) | CHRM1 | |
| SCHEMBL2488465 | 0.85 | CHRM1 (0.41) | CHRM1PTGER2GRIN2B | |
| SCHEMBL2491881 | 0.84 | ERN1 (0.42) | CHRM1GRIN2B | |
| SCHEMBL2488025 | 0.84 | CHRM1 (0.41) | CHRM1GRIN2B | |
| SCHEMBL2487494 | 0.83 | CHRM1 (0.40) | CHRM1 | |
| SCHEMBL2490966 | 0.82 | CHRM1 (0.42) | CHRM1CAPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037739-B1 | BENZYL-SUBSTITUTED QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2011-10-26 | — | — | EP | claimed |