Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 5/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 8/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | ABCC1 | P33527 | 4/20 | 0.36 |
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2492208 | 0.90 | CHRM1 (0.41) | CHRM1ERN1 | |
| SCHEMBL2486084 | 0.90 | CHRM1 (0.53) | CHRM1P2RX7 | |
| SCHEMBL2487494 | 0.87 | CHRM1 (0.40) | CHRM1 | |
| SCHEMBL2492205 | 0.87 | CHRM1 (0.41) | CHRM1 | |
| SCHEMBL2487906 | 0.86 | CHRM1 (0.60) | CHRM1ABCB1ERN1TOP2ATOP2B | |
| SCHEMBL2488465 | 0.85 | CHRM1 (0.41) | CHRM1P2RX7 | |
| SCHEMBL2488348 | 0.85 | CHRM1 (0.40) | CHRM1 | |
| SCHEMBL2487485 | 0.85 | CHRM1 (0.45) | CHRM1MKNK1MKNK2 | |
| SCHEMBL2491881 | 0.84 | ERN1 (0.42) | CHRM1ERN1MKNK1MKNK2 | |
| SCHEMBL2488025 | 0.84 | CHRM1 (0.41) | CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037739-B1 | BENZYL-SUBSTITUTED QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2011-10-26 | — | — | EP | claimed |