SCHEMBL24875503

SCHEMBL24875503

COC(=O)Cc1cc(F)ccc1C(F)(F)F

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 1/20 0.43
P2RX7 Q99572 3/20 0.42
NOTUM Q6P988 1/20 0.41
IDO1 P14902 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.40
NTRK1 P04629 3/20 0.40
POLQ O75417 1/20 0.39
SLC6A2 P23975 2/20 0.39
SLC6A4 P31645 2/20 0.39
TP53 P04637 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
HTT P42858 2/20 0.39
ALDH1A1 P00352 2/20 0.39
GAA P10253 1/20 0.39
GFER P55789 1/20 0.39
KDM4E B2RXH2 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
HDAC3 O15379 1/20 0.38
HDAC1 Q13547 1/20 0.38
HDAC2 Q92769 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20832037 0.88 IDO1 (0.51) EPHX2P2RX7IDO1POLQHDAC3
SCHEMBL6862285 0.85 ALDH1A1 (0.44) EPHX2P2RX7POLQTP53L3MBTL1
SCHEMBL2858243 0.84 CES2 (0.47) EPHX2NOTUMSMN1; SMN2POLQALDH1A1
SCHEMBL2946105 0.83 HTT (0.53) P2RX7NOTUMPOLQHTTALDH1A1
SCHEMBL14420158 0.82 ALDH1A1 (0.43) EPHX2NOTUMSMN1; SMN2HTTALDH1A1
SCHEMBL154096 0.80 RXRA (0.49) P2RX7IDO1NTRK1POLQSLC6A2
SCHEMBL8063678 0.80 MAPK8 (0.46) SMN1; SMN2HTTALDH1A1HSP90AB1
SCHEMBL23200513 0.79 IDO1 (0.44) P2RX7IDO1NTRK1POLQSLC6A2
SCHEMBL871601 0.79 POLQ (0.55) EPHX2IDO1POLQHTTALDH1A1
SCHEMBL23362766 0.79 SMN1; SMN2 (0.52) SMN1; SMN2HTTALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4366829-A1 PHENYL ACETAMIDE BASED IL-17A MODULATORS AND USES THEREOF Dice Alpha, Inc. (US) 2024-05-15 EP disclosed
CN-117957212-A IL-17A modulators based on phenylacetamide and uses thereof 戴斯阿尔法公司 2024-04-30 CN disclosed
WO-2023283453-A1 PHENYL ACETAMIDE BASED IL-17A MODULATORS AND USES THEREOF DICE ALPHA, INC. (US) 2023-01-12 WO disclosed
WO-2023283453-A1 PHENYL ACETAMIDE BASED IL-17A MODULATORS AND USES THEREOF DICE ALPHA, INC. (US) 2023-01-12 WO disclosed