Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 1/20 | 0.49 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.49 |
| ▸ | HNF4A | P41235 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18378524 | 0.86 | ADORA2A (0.47) | PDCD1CD274HNF4AHDAC4HDAC2 | |
| SCHEMBL18189726 | 0.83 | PDCD1 (0.44) | PDCD1CD274HNF4AHDAC4HDAC2 | |
| SCHEMBL3621894 | 0.83 | ADORA2A (0.50) | PDCD1CD274HNF4AHDAC4HDAC2 | |
| SCHEMBL3464186 | 0.83 | DPP4 (0.54) | PDCD1CD274TAAR1SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL6048562 | 0.81 | DPP4 (0.52) | PDCD1CD274TAAR1SLC6A2SLC6A4 | |
| Bromide SCHEMBL27653706 | 0.81 | DPP4 (0.52) | PDCD1CD274TAAR1SLC6A2SLC6A4 | |
| SCHEMBL1698715 | 0.80 | GABRA1 (0.54) | SLC6A2SLC6A4ALDH1A1TSHRHSD17B10 | |
| SCHEMBL26574289 | 0.80 | PDCD1 (0.46) | PDCD1CD274TAAR1SLC6A2SLC6A4 | |
| SCHEMBL11048530 | 0.80 | CD274 (0.65) | PDCD1CD274TAAR1SLC6A2SLC6A4 | |
| SCHEMBL10911038 | 0.79 | GABRA1 (0.61) | PDCD1CD274HNF4AHDAC4HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367078-B2 | Kinase inhibitor compounds | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2013-02-05 | — | — | US | claimed |
| US-9133039-B2 | Kinase inhibitor compounds | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2015-09-15 | — | — | US | disclosed |
| US-9133039-B2 | Kinase inhibitor compounds | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2015-09-15 | — | — | US | disclosed |
| US-20140248634-A1 | VIMENTIN AS A BIOMARKER FOR THE PROGRESSION OF MYELOPROLIFERATIVE NEOPLASMS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (US) | 2014-09-04 | — | — | US | disclosed |
| US-20140193518-A1 | KINASE INHIBITOR COMPOUNDS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2014-07-10 | — | — | US | disclosed |
| US-20140193518-A1 | KINASE INHIBITOR COMPOUNDS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2014-07-10 | — | — | US | disclosed |
| WO-2013019655-A2 | VIMENTIN AS A BIOMARKER FOR THE PROGRESSION OF MYELOPROLIFERATIVE NEOPLASMS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION (US) | 2013-02-07 | — | — | WO | disclosed |
| US-8367078-B2 | Kinase inhibitor compounds | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2013-02-05 | — | — | US | disclosed |
| US-8367078-B2 | Kinase inhibitor compounds | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2013-02-05 | — | — | US | disclosed |
| CN-102395557-A | Kinase inhibitor compounds | UNIV FLORIDA | 2012-03-28 | — | — | CN | disclosed |
| US-20110301159-A1 | KINASE INHIBITOR COMPOUNDS | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-12-08 | — | — | US | disclosed |
| EP-2376425-A2 | KINASE INHIBITOR COMPOUNDS | University of Florida Research Foundation, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| US-7834062-B2 | Aminoalkylphenols, methods of using and making the same | MERCK SHARP & DOHME CORP. (US) | 2010-11-16 | — | — | US | disclosed |
| US-20100278933-A1 | KINASE INHIBITOR COMPOUNDS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC (US) | 2010-11-04 | — | — | US | disclosed |
| US-20100278933-A1 | KINASE INHIBITOR COMPOUNDS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC (US) | 2010-11-04 | — | — | US | disclosed |
| WO-2010068710-A2 | KINASE INHIBITOR COMPOUNDS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2010-06-17 | — | — | WO | disclosed |
| US-20090298949-A1 | AMINOALKYLPHENOLS, METHODS OF USING AND MAKING THE SAME | MERCK SHARP & DOHME LLC | 2009-12-03 | — | — | US | disclosed |
| US-7589127-B2 | Aminoalkylphenols, methods of using and making the same | MERCK & CO., INC. (US) | 2009-09-15 | — | — | US | disclosed |
| US-20050234265-A1 | Aminoalkylphenols, methods of using and making the same | MERCK SHARP & DOHME LLC | 2005-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100278933-A1 | KINASE INHIBITOR COMPOUNDS | MAP3K1, MAP3K2, MAP3K6 | PDCD1 1452/4885CD274 2433/4885HNF4A 1762/4885 |
| US-20140193518-A1 | KINASE INHIBITOR COMPOUNDS | MAP3K1, MAP3K2, MAP3K6 | PDCD1 1452/4885CD274 2433/4885HNF4A 1762/4885 |
| US-20090298949-A1 | AMINOALKYLPHENOLS, METHODS OF USING AND MAKING THE SAME | NPEPPS, PHOSPHO1, LNPEP | PDCD1 3656/4885CD274 4368/4885HNF4A 3269/4885 |
| US-20050234265-A1 | Aminoalkylphenols, methods of using and making the same | NPEPPS, PHOSPHO1, LNPEP | PDCD1 3656/4885CD274 4368/4885HNF4A 3269/4885 |
| US-20110301159-A1 | KINASE INHIBITOR COMPOUNDS | JAK2, JAK1, JAK3 | PDCD1 1269/4885CD274 2358/4885HNF4A 3467/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.