Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.42 |
| ▸ | NOS1 | P29475 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 4/20 | 0.41 |
| ▸ | FLT3 | P36888 | 4/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.41 |
| ▸ | METAP2 | P50579 | 8/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.36 |
| ▸ | CDK1 | P06493 | 3/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.36 |
| ▸ | CDK9 | P50750 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24777034 | 0.83 | IDO1 (0.46) | IDO1NOS1CDK2FLT3CCNA1 | |
| SCHEMBL27358505 | 0.83 | IDO1 (0.46) | IDO1NOS1CDK2FLT3CCNA1 | |
| SCHEMBL13676393 | 0.81 | IDO1 (0.44) | IDO1NOS1CDK2FLT3CCNA1 | |
| SCHEMBL30641259 | 0.79 | TDO2 (0.43) | IDO1NOS1CDK2FLT3CCNA1 | |
| SCHEMBL21379129 | 0.79 | TDO2 (0.43) | IDO1NOS1CDK2FLT3CCNA1 | |
| SCHEMBL13692760 | 0.78 | NOS1 (0.44) | IDO1NOS1CDK2FLT3CCNA1 | |
| SCHEMBL23588714 | 0.76 | CDK2 (0.41) | IDO1CDK2FLT3CCNA1METAP2 | |
| SCHEMBL23588717 | 0.76 | METAP2 (0.40) | IDO1NOS1CDK2FLT3CCNA1 | |
| SCHEMBL24854121 | 0.76 | IDO1 (0.40) | IDO1NOS1CDK2FLT3CCNA1 | |
| SCHEMBL31041019 | 0.75 | IDO1 (0.43) | IDO1NOS1CDK2FLT3CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023283213-A1 | TRICYCLIC COMPOUNDS AS INHIBITORS OF KRAS | INCYTE CORPORATION (US) | 2023-01-12 | — | — | WO | disclosed |