Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 1/20 | 0.43 |
| ▸ | YAP1 | P46937 | 1/20 | 0.43 |
| ▸ | WDR5 | P61964 | 8/20 | 0.37 |
| ▸ | TNNI3K | Q59H18 | 3/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30114144 | 1.00 | TEAD1 (0.43) | TEAD1YAP1WDR5TNNI3KTGFBR1 | |
| SCHEMBL24879865 | 0.89 | TEAD1 (0.45) | TEAD1YAP1WDR5TNNI3KNPC1 | |
| SCHEMBL24880072 | 0.81 | WDR5 (0.39) | WDR5NPC1MAPTRAB9AKMT2A | |
| SCHEMBL30113958 | 0.81 | WDR5 (0.39) | WDR5NPC1MAPTRAB9AKMT2A | |
| SCHEMBL24880000 | 0.78 | TEAD1 (0.47) | TEAD1YAP1WDR5TNNI3KNPC1 | |
| SCHEMBL24631139 | 0.77 | WDR5 (0.44) | WDR5NPC1MAPTRAB9AKMT2A | |
| SCHEMBL24879863 | 0.76 | TEAD1 (0.51) | TEAD1YAP1TNNI3KBRAFMAPT | |
| SCHEMBL24631134 | 0.75 | WDR5 (0.44) | WDR5NPC1MAPTRAB9AKMT2A | |
| SCHEMBL24879883 | 0.74 | TEAD1 (0.50) | TEAD1YAP1TNNI3KBRAFMAPT | |
| SCHEMBL30114160 | 0.74 | TEAD1 (0.50) | TEAD1YAP1TNNI3KBRAFMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115594680-A | TEAD inhibitor | 武汉人福创新药物研发中心有限公司（CN） | 2023-01-13 | — | — | CN | disclosed |
| WO-2023280254-A1 | TEAD INHIBITOR | 武汉人福创新药物研发中心有限公司 | 2023-01-12 | — | — | WO | disclosed |