Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 2/20 | 0.47 |
| ▸ | YAP1 | P46937 | 1/20 | 0.47 |
| ▸ | TNNI3K | Q59H18 | 7/20 | 0.37 |
| ▸ | WDR5 | P61964 | 4/20 | 0.35 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24879865 | 0.85 | TEAD1 (0.45) | TEAD1YAP1TNNI3KWDR5ALDH3A1 | |
| SCHEMBL24880305 | 0.83 | WDR5 (0.37) | WDR5NPC1SMN1; SMN2LMNAMAPT | |
| SCHEMBL30114128 | 0.82 | TEAD1 (0.45) | TEAD1YAP1TNNI3KALDH3A1IDH1 | |
| SCHEMBL30114368 | 0.82 | TEAD1 (0.45) | TEAD1YAP1TNNI3KALDH3A1IDH1 | |
| SCHEMBL24879946 | 0.82 | TEAD1 (0.45) | TEAD1YAP1TNNI3KALDH3A1IDH1 | |
| SCHEMBL24880016 | 0.82 | TEAD1 (0.45) | TEAD1YAP1TNNI3KALDH3A1IDH1 | |
| SCHEMBL24879863 | 0.79 | TEAD1 (0.51) | TEAD1YAP1TNNI3KMAPT | |
| SCHEMBL24631145 | 0.79 | TEAD1 (0.40) | TEAD1YAP1TNNI3KWDR5SMN1; SMN2 | |
| SCHEMBL24879914 | 0.78 | TEAD1 (0.44) | TEAD1YAP1TNNI3KWDR5NPC1 | |
| SCHEMBL24879993 | 0.78 | TEAD1 (0.43) | TEAD1YAP1TNNI3KWDR5NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115594680-A | TEAD inhibitor | 武汉人福创新药物研发中心有限公司（CN） | 2023-01-13 | — | — | CN | disclosed |
| WO-2023280254-A1 | TEAD INHIBITOR | 武汉人福创新药物研发中心有限公司 | 2023-01-12 | — | — | WO | disclosed |
| WO-2023280254-A1 | TEAD INHIBITOR | 武汉人福创新药物研发中心有限公司 | 2023-01-12 | — | — | WO | disclosed |