Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 11/20 | 0.35 |
| ▸ | PAK3 | O75914 | 1/20 | 0.32 |
| ▸ | PAK2 | Q13177 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.31 |
| ▸ | KDR | P35968 | 2/20 | 0.31 |
| ▸ | FLT3 | P36888 | 2/20 | 0.31 |
| ▸ | CDK14 | O94921 | 3/20 | 0.30 |
| ▸ | CCNY | Q8ND76 | 3/20 | 0.30 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.30 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2486096 | 0.86 | XDH (0.37) | PAK1FGFR1FGFR2 | |
| Trifluoroacetic Acid SCHEMBL2487191 | 0.77 | ATR (0.32) | PAK1KDRFLT3CCNE2CCNE1 | |
| Trifluoroacetic Acid SCHEMBL2487366 | 0.77 | ROCK2 (0.46) | — | |
| Trifluoroacetic Acid SCHEMBL2490577 | 0.76 | KDR (0.50) | PAK1PDGFRBKDR | |
| SCHEMBL12316273 | 0.74 | ENPP2 (0.43) | PAK1 | |
| Trifluoroacetic Acid SCHEMBL2487212 | 0.74 | KDR (0.50) | PDGFRBKDR | |
| Trifluoroacetic Acid SCHEMBL2487091 | 0.73 | DPP8 (0.35) | PAK1 | |
| SCHEMBL2485132 | 0.72 | PTGS1 (0.45) | PAK1PDGFRBKDRCCNE2CCNE1 | |
| SCHEMBL2804960 | 0.71 | PAK1 (0.37) | PAK1PDGFRBKDRFLT3CCNE2 | |
| SCHEMBL2486452 | 0.71 | NR1H2 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379551-A1 | SUBSTITUTED PYRAZOLO [3, 4-B]PYRIDINE COMPOUNDS | ArQule, Inc. (US) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010078427-A1 | SUBSTITUTED PYRAZOLO [3, 4-B] PYRIDINE COMPOUNDS | ARQULE, INC. (US) | 2010-07-08 | — | — | WO | disclosed |