SCHEMBL24880497

SCHEMBL24880497

CN1CC2(CCN(c3ccc(C#Cc4ccc5c(c4)CN(C4CCC(=O)NC4=O)C5=O)nn3)C2)C1

nearest known ligand 0.47

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 8/20 0.47
▸ IKZF2 Q9UKS7 12/20 0.44
▸ CSNK1A1 P48729 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL27216595 0.92 CRBN (0.46) CRBNIKZF2CSNK1A1
SCHEMBL30080867 0.88 CRBN (0.42) CRBNIKZF2CSNK1A1
SCHEMBL27216611 0.88 CRBN (0.42) CRBNIKZF2CSNK1A1
SCHEMBL30080888 0.87 CRBN (0.41) CRBNIKZF2CSNK1A1
SCHEMBL30195157 0.78 CRBN (0.47) CRBNIKZF2CSNK1A1
SCHEMBL30194960 0.77 IKZF2 (0.60) CRBNIKZF2CSNK1A1
SCHEMBL24250708 0.75 CRBN (0.59) CRBNIKZF2CSNK1A1
SCHEMBL24637376 0.75 CRBN (0.69) CRBNIKZF2CSNK1A1
SCHEMBL30569130 0.75 CRBN (0.69) CRBNIKZF2CSNK1A1
SCHEMBL23250036 0.74 CRBN (0.62) CRBNIKZF2CSNK1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023280237-A1 SYNTHESIS AND APPLICATION OF PHOSPHATASE DEGRADER 海创药业股份有限公司 2023-01-12 — — WO disclosed
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