Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 2/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | USP14 | P54578 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30066240 | 0.89 | DGAT1 (0.45) | DGAT1PDE10AAKR1C3DEGS1PPARG | |
| SCHEMBL2145424 | 0.86 | DGAT1 (0.49) | DGAT1HPGDSMN1; SMN2DEGS1HRH3 | |
| SCHEMBL29990449 | 0.85 | PPARG (0.45) | DGAT1PDE10AAKR1C3DEGS1PPARG | |
| SCHEMBL24670864 | 0.85 | PPARG (0.45) | DGAT1PDE10AAKR1C3DEGS1PPARG | |
| SCHEMBL10379966 | 0.84 | USP14 (0.44) | DGAT1USP14ALDH1A1CHRM4OPRK1 | |
| SCHEMBL14511135 | 0.84 | DGAT1 (0.56) | DGAT1HPGDSMN1; SMN2DEGS1HRH3 | |
| SCHEMBL18400834 | 0.84 | DGAT1 (0.48) | DGAT1HPGDSMN1; SMN2DEGS1HRH3 | |
| SCHEMBL374689 | 0.83 | USP30 (0.55) | DGAT1HPGDSMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL24880627 | 0.83 | OXTR (0.39) | DGAT1PDE10AUSP14AKR1C3HPGD | |
| SCHEMBL3188250 | 0.83 | SMN1; SMN2 (0.67) | DGAT1HPGDSMN1; SMN2HRH3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023283610-A1 | COMPOUNDS FOR TARGETING DEGRADATION OF IRAK4 PROTEINS | BIOGEN MA INC. (US) | 2023-01-12 | — | — | WO | disclosed |