Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.66 |
| ▸ | HPGD | P15428 | 6/20 | 0.66 |
| ▸ | ESR1 | P03372 | 2/20 | 0.66 |
| ▸ | HMGB1 | P09429 | 2/20 | 0.66 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.66 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.66 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | GGT1 | P19440 | 1/20 | 0.66 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.66 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.66 |
| ▸ | BLM | P54132 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1721235 | 0.83 | KDM4E (0.78) | KDM4EALDH1A1HSD17B10HPGDESR1 | |
| SCHEMBL766761 | 0.83 | KDM4E (0.70) | KDM4EALDH1A1HSD17B10HPGDESR1 | |
| SCHEMBL8530334 | 0.82 | ELANE (0.63) | KDM4EALDH1A1HSD17B10HPGDESR1 | |
| SCHEMBL5696260 | 0.82 | SERPINE1 (0.43) | KDM4EALDH1A1HSD17B10HPGDESR1 | |
| SCHEMBL30524282 | 0.82 | SERPINE1 (0.43) | KDM4EALDH1A1HSD17B10HPGDESR1 | |
| SCHEMBL11208120 | 0.81 | KDM4E (0.79) | KDM4EALDH1A1HSD17B10HPGDESR1 | |
| SCHEMBL13189200 | 0.79 | KDM4E (0.66) | KDM4EALDH1A1HSD17B10HPGDESR1 | |
| SCHEMBL1810676 | 0.79 | KDM4E (0.66) | KDM4EALDH1A1HSD17B10HPGDESR1 | |
| Aspirin SCHEMBL1331740 | 0.79 | KDM4E (1.00) | KDM4EALDH1A1HSD17B10HPGDESR1 | |
| Aspirin SCHEMBL7580 | 0.79 | KDM4E (1.00) | KDM4EALDH1A1HSD17B10HPGDESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0417514-A2 | Method for preparing reactively terminated polycarbonates | GENERAL ELECTRIC COMPANY (US) | 1991-03-20 | — | — | EP | claimed |
| JP-3152126-A | — | — | None | — | — | JP | disclosed |
| EP-2588107-A1 | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET | Takeda Pharmaceutical Company Limited (JP) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003338-A1 | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-01-05 | — | — | WO | disclosed |
| EP-2313407-A1 | cMET INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2011-04-27 | — | — | EP | disclosed |
| WO-2010019899-A1 | cMET INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-02-18 | — | — | WO | disclosed |
| JP-H03152126-A | PRODUCTION OF REACTIVELY TERMINATED POLYCARBONATE | GENERAL ELECTRIC CO <GE> | 1991-06-28 | — | — | JP | disclosed |
| EP-0417511-A2 | Method for preparing block polyphenylene ether-polycarbonates | GENERAL ELECTRIC COMPANY (US) | 1991-03-20 | — | — | EP | disclosed |
| EP-0417514-A2 | Method for preparing reactively terminated polycarbonates | GENERAL ELECTRIC COMPANY (US) | 1991-03-20 | — | — | EP | disclosed |
| EP-0417514-A2 | Method for preparing reactively terminated polycarbonates | GENERAL ELECTRIC COMPANY (US) | 1991-03-20 | — | — | EP | disclosed |
| US-4973628-A | MELT PROCESSABILITY, SALICYLATE ENDCAPPED POLYCARBONATE, TRANSESTERIFICATION | GENERAL ELECTRIC COMPANY (US) | 1990-11-27 | — | — | US | disclosed |