Toltrazuril

Toltrazuril

SCHEMBL248912

Cc1cc(-n2c(=O)[nH]c(=O)n(C)c2=O)ccc1Oc1ccc(SC(F)(F)F)cc1

nearest known ligand 0.57

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
NTRK1 P04629 15/20 0.57
NTRK2 Q16620 15/20 0.57
IGF1R P08069 5/20 0.57
FGFR1 P11362 5/20 0.57
NTRK3 Q16288 11/20 0.46
BCAT2 O15382 4/20 0.38
BCAT1 P54687 4/20 0.38
ATM Q13315 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Toltrazuril SCHEMBL21812043 1.00 NTRK1 (0.57) NTRK1NTRK2IGF1RFGFR1NTRK3
Toltrazuril SCHEMBL29509205 1.00 NTRK1 (0.57) NTRK1NTRK2IGF1RFGFR1NTRK3
SCHEMBL13780159 0.92 NTRK1 (0.48) NTRK1NTRK2IGF1RFGFR1NTRK3
Toltrazuril SCHEMBL19436333 0.92 NTRK1 (0.49) NTRK1NTRK2IGF1RFGFR1NTRK3
SCHEMBL10975351 0.91 NTRK1 (0.52) NTRK1NTRK2IGF1RFGFR1NTRK3
SCHEMBL10525684 0.88 NTRK1 (0.58) NTRK1NTRK2IGF1RFGFR1NTRK3
SCHEMBL20328512 0.88 NTRK1 (0.76) NTRK1NTRK2IGF1RFGFR1NTRK3
SCHEMBL11478539 0.88 NTRK1 (0.45) NTRK1NTRK2IGF1RFGFR1NTRK3
SCHEMBL15783169 0.88 NTRK1 (0.55) NTRK1NTRK2IGF1RFGFR1NTRK3
SCHEMBL10525747 0.86 NTRK1 (0.51) NTRK1NTRK2IGF1RFGFR1NTRK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3014 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119971057-A Suspending agent composition for livestock, preparation method thereof, method for preparing suspension and application 佛山市正典生物技术有限公司 2025-05-13 CN claimed
CN-119837827-A Suspending agent composition for automatic drinking line dosing and automatic drinking line dosing method 资兴市动物疫病预防控制中心 2025-04-18 CN claimed
US-12274830-B2 Nitric oxide inhalation therapy for infants with bronchiolitis BEYOND AIR LTD (IL) 2025-04-15 US claimed
CN-115501273-B Application of traditional Chinese medicine compound effective extract in preparation of medicine for resisting eimeria tenella 广西大学 2025-03-25 CN claimed
EP-4082524-B1 TRIAZINE FORMULATIONS CEVA SANTE ANIMALE SA (FR) 2025-02-26 EP claimed
US-20250041328-A1 FORMULATION FOR THE USE IN THE SIMULTANEOUS TREATMENT OF COCCIDIAL INFECTIONS AND IRON DEFICIENCIES ELANCO ANIMAL HEALTH GMBH (DE) 2025-02-06 US claimed
US-12150952-B2 Formulation for the use in the simultaneous treatment of coccidial infections and iron deficiencies ELANCO ANIMAL HEALTH GMBH (DE) 2024-11-26 US claimed
US-20240382574-A1 METHODS AND COMPOSITIONS FOR ORALLY DOSING ANIMALS Animal Science Products, Inc. (US) 2024-11-21 US claimed
US-20240173512-A1 METHODS FOR POTENTIATING ANTIMICROBIAL AGENTS STREETERVILLE CAPITAL, LLC 2024-05-30 US claimed
CN-116672360-B Composition of toltrazuril and iron glucoheptonate 重庆汉佩生物科技有限公司 2024-05-14 CN claimed
WO-2000037064-A2 TRIAZINEONE COMPOUNDS FOR TREATING DISEASES DUE TO SARCOSYSTIS, NEOSPORA AND TOXOPLASMA BAYER CORPORATION (US) 2000-06-29 WO claimed
WO-2000037084-A1 TRIAZINEONE COMPOUNDS FOR TREATING DISEASES DUE TO SARCOSYSTIS, NEOSPORA AND TOXOPLASMA BAYER CORPORATION (US) 2000-06-29 WO claimed
WO-2000019964-A2 NOVEL COMPOSITIONS AND METHODS FOR PREVENTION AND TREATMENT OF PROTOZOAL DISEASE NEW ACE RESEARCH COMPANY (US) 2000-04-13 WO claimed
US-5883095-A TRIAZINE ANTICOCCIDAL USING CLAZURIL, DICLAZURIL, TOLTRAZURIL OR LETRAZURIL UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) 1999-03-16 US claimed
WO-1998043644-A1 FORMULATIONS AND METHODS TO TREAT AND PREVENT EQUINE PROTOZOAL MYELOENCEPHALITIS GRANSTROM DAVID (US) 1998-10-08 WO claimed
US-5646135-A ADMINISTERING, IN SEQUENCE, TWO DIFFERENT ANTICOCCIDIAL COMPOUNDS TO POULTRY MERCK & CO., INC. (US) 1997-07-08 US claimed
US-4874860-A Process for preparing 1,3,5-triazinetriones BAYER AKTIENGESELLSCHAFT (DE) 1989-10-17 US claimed
US-4837216-A APPLYING A TRIAZINETRIONE COMPOUNDS BAYER AKTIENGESELLSCHAFT (DE) 1989-06-06 US claimed
US-4826842-A TRIAZINETRIONE DERIVATIVE BAYER AKTIENGESELLSCHAFT (DE) 1989-05-02 US claimed
EP-0116175-B1 COMPOSITIONS FOR THE TREATMENT OF COCCIDIOSE BAYER AG (DE) 1989-02-15 EP claimed