SCHEMBL24891779

SCHEMBL24891779

COc1cc(C2=CCN(C)CC2)ccc1NC(=O)c1ccc(C(=O)Nc2ccc(CNC(=O)OC(C)(C)C)cc2)cc1

nearest known ligand 0.47

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 4/20 0.47
NAMPT P43490 4/20 0.44
QDPR P09417 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43
ALDH1A1 P00352 2/20 0.43
HPGD P15428 2/20 0.43
CFTR P13569 1/20 0.41
KDM4E B2RXH2 1/20 0.41
MAPT P10636 1/20 0.41
CD274 Q9NZQ7 1/20 0.40
ROCK2 O75116 1/20 0.40
CYP3A4 P08684 1/20 0.40
ABCB1 P08183 3/20 0.39
ABCG2 Q9UNQ0 3/20 0.39
HDAC3 O15379 1/20 0.38
HDAC2 Q92769 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24891773 0.91 NAMPT (0.48) HDAC1NAMPTQDPRHDAC6ALDH1A1
SCHEMBL24891939 0.82 NAMPT (0.38) HDAC1NAMPTQDPRHDAC6ALDH1A1
SCHEMBL24670226 0.80 NAMPT (0.57) HDAC1NAMPTHDAC6MAPTCD274
SCHEMBL24892276 0.80 NAMPT (0.57) HDAC1NAMPTHDAC6MAPTCD274
SCHEMBL24891656 0.79 NAMPT (0.53) HDAC1NAMPTHDAC6ALDH1A1KDM4E
SCHEMBL24891726 0.79 ALDH1A1 (0.43) HDAC1NAMPTQDPRALDH1A1HPGD
SCHEMBL24891842 0.78 NAMPT (0.45) HDAC1NAMPTHDAC6MAPT
SCHEMBL24891980 0.76 NAMPT (0.52) HDAC1NAMPTHDAC6MAPTCD274
SCHEMBL24892051 0.75 NAMPT (0.53) HDAC1NAMPTHDAC6MAPT
SCHEMBL30182051 0.75 NAMPT (0.53) HDAC1NAMPTHDAC6MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023287736-A1 NOVEL BIS-AMIDE CONTAINING COMPOUNDS EXHIBITING ANTIFUNGAL ACTIVITY AND THEIR METHOD OF USE FOX CHASE CHEMICAL DIVERSITY CENTER, INC. (US) 2023-01-19 WO disclosed