Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 20/20 | 0.68 |
| ▸ | BMP2K | Q9NSY1 | 4/20 | 0.68 |
| ▸ | GAK | O14976 | 3/20 | 0.68 |
| ▸ | DAPK1 | P53355 | 3/20 | 0.68 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.68 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.68 |
| ▸ | JAK2 | O60674 | 2/20 | 0.68 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.68 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.68 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.68 |
| ▸ | DMPK | Q09013 | 1/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.55 |
| ▸ | CIT | O14578 | 2/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.55 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.55 |
| ▸ | MYLK2 | Q9H1R3 | 2/20 | 0.52 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24897683 | 1.00 | AAK1 (0.68) | AAK1BMP2KGAKDAPK1MKNK2 | |
| SCHEMBL27220584 | 0.93 | AAK1 (0.68) | AAK1BMP2KGAKDAPK1MKNK2 | |
| SCHEMBL27220582 | 0.93 | AAK1 (0.68) | AAK1BMP2KGAKDAPK1MKNK2 | |
| SCHEMBL24897689 | 0.92 | AAK1 (0.81) | AAK1BMP2KGAKDAPK1MKNK2 | |
| SCHEMBL24897831 | 0.92 | AAK1 (0.81) | AAK1BMP2KGAKDAPK1MKNK2 | |
| SCHEMBL24897651 | 0.88 | AAK1 (0.67) | AAK1BMP2KGAKDAPK1MKNK2 | |
| SCHEMBL24897632 | 0.88 | AAK1 (0.67) | AAK1BMP2KGAKDAPK1MKNK2 | |
| SCHEMBL29174168 | 0.83 | AAK1 (0.56) | AAK1BMP2KGAKDAPK1MKNK2 | |
| SCHEMBL24897569 | 0.83 | AAK1 (0.77) | AAK1BMP2KGAKDAPK1MKNK2 | |
| SCHEMBL24897669 | 0.83 | AAK1 (0.77) | AAK1BMP2KGAKDAPK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240343720-A1 | AAK1 INHIBITOR AND USE THEREOF | XIZANG HAISCO PHARMACEUTICAL CO., LTD. (CN) | 2024-10-17 | — | — | US | disclosed |
| EP-4371980-A1 | AAK1 INHIBITOR AND USE THEREOF | Xizang Haisco Pharmaceutical Co., Ltd. (CN) | 2024-05-22 | — | — | EP | disclosed |
| CN-117715899-A | AAK1 inhibitors and uses thereof | 西藏海思科制药有限公司 | 2024-03-15 | — | — | CN | disclosed |
| WO-2023284838-A1 | AAK1 INHIBITOR AND USE THEREOF | 四川海思科制药有限公司 | 2023-01-19 | — | — | WO | disclosed |
| WO-2023284838-A1 | AAK1 INHIBITOR AND USE THEREOF | 四川海思科制药有限公司 | 2023-01-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240343720-A1 | AAK1 INHIBITOR AND USE THEREOF | AAK1, ADCK1, ADCK5 | AAK1 1/4885BMP2K 440/4885GAK 131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.